Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 13/20 | 0.78 |
| ▸ | THRA | P10827 | 9/20 | 0.78 |
| ▸ | MEN1 | O00255 | 6/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.64 |
| ▸ | LMNA | P02545 | 5/20 | 0.64 |
| ▸ | PPARG | P37231 | 3/20 | 0.64 |
| ▸ | PCNA | P12004 | 2/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.64 |
| ▸ | TSHR | P16473 | 1/20 | 0.64 |
| ▸ | GABRP | O00591 | 1/20 | 0.64 |
| ▸ | GABRD | O14764 | 1/20 | 0.64 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.64 |
| ▸ | F2 | P00734 | 1/20 | 0.64 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.64 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.64 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.64 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.64 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.64 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.64 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6827509 | 1.00 | THRB (0.78) | THRBTHRAMEN1KMT2ALMNA | |
| SCHEMBL23683142 | 0.93 | THRB (0.87) | THRBTHRAMEN1KMT2ALMNA | |
| SCHEMBL20143740 | 0.93 | THRB (0.87) | THRBTHRAMEN1KMT2ALMNA | |
| SCHEMBL14212295 | 0.92 | THRB (0.67) | THRBTHRAMEN1KMT2ALMNA | |
| SCHEMBL20107338 | 0.90 | THRB (0.80) | THRBTHRAMEN1KMT2ALMNA | |
| SCHEMBL6825389 | 0.90 | THRB (0.80) | THRBTHRAMEN1KMT2ALMNA | |
| SCHEMBL25775861 | 0.90 | THRB (0.80) | THRBTHRAMEN1KMT2ALMNA | |
| SCHEMBL7271821 | 0.89 | THRB (0.77) | THRBTHRAMEN1KMT2ALMNA | |
| SCHEMBL10678814 | 0.89 | THRB (0.77) | THRBTHRAMEN1KMT2ALMNA | |
| SCHEMBL6825785 | 0.89 | THRB (0.93) | THRBTHRAMEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021032218-A1 | HETEROCYCLIC THR-β RECEPTOR AGONIST COMPOUND AND PREPARATION METHOD AND USE THEREFOR | 苏州闻天医药科技有限公司 | 2021-02-25 | — | — | WO | disclosed |
| EP-3736264-A1 | A NON-RADIOACTIVE IMMUNO-ASSAY FOR 3,5-DIIODO-O-[3-IODOPHENYL]-L-TYROSINE DETECTION AND QUANTITATION | Bracco Imaging SPA (IT) | 2020-11-11 | — | — | EP | disclosed |
| EP-3260443-B1 | A PHARMACEUTICAL COMPOSITION COMPRISING A SULFATED DERIVATIVE OF 3,5-DIIODO-O-[3-IODOPHENYL]-L-TYROSINE | BRACCO IMAGING SPA (IT) | 2020-10-07 | — | — | EP | disclosed |
| EP-2694471-B1 | PROCESS FOR THE PREPARATION OF A SULFATED DERIVATIVE OF 3,5-DIIODO-O-[3-IODOPHENYL]-L-TYROSINE | BRACCO IMAGING SPA (IT) | 2017-08-02 | — | — | EP | disclosed |