Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STS | P08842 | 1/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.39 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CETP | P11597 | 1/20 | 0.37 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
| ▸ | RXRA | P19793 | 1/20 | 0.37 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1909822 | 0.88 | USP30 (0.43) | STSUSP30NR1H2NR1H3CETP | |
| SCHEMBL22639146 | 0.86 | GRM2 (0.41) | GRM2TAAR1RORC | |
| SCHEMBL14932460 | 0.81 | GRM2 (0.41) | STSGRM2USP30UCHL1SMN1; SMN2 | |
| SCHEMBL24428588 | 0.79 | CHRM2 (0.40) | SMN1; SMN2NR1H2NR1H3CETPRORC | |
| SCHEMBL17986553 | 0.75 | STS (0.39) | STSGRM2SMN1; SMN2TAAR1TP53 | |
| SCHEMBL10251800 | 0.73 | RIPK1 (0.38) | SMN1; SMN2 | |
| SCHEMBL21268162 | 0.73 | STS (0.36) | STSSMN1; SMN2NR1H2NR1H3TP53 | |
| SCHEMBL17986554 | 0.73 | STS (0.36) | STSSMN1; SMN2NR1H2NR1H3TP53 | |
| SCHEMBL21268160 | 0.73 | STS (0.36) | STSSMN1; SMN2NR1H2NR1H3TP53 | |
| SCHEMBL16619599 | 0.73 | STS (0.36) | STSSMN1; SMN2NR1H2NR1H3TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3199517-A1 | NEPRILYSIN INHIBITORS | Theravance Biopharma R&D IP, LLC (US) | 2017-08-02 | — | — | EP | disclosed |