Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 2/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
| ▸ | MME | P08473 | 4/20 | 0.36 |
| ▸ | MMEL1 | Q495T6 | 4/20 | 0.36 |
| ▸ | ACE | P12821 | 2/20 | 0.36 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14900527 | 0.83 | GRM2 (0.43) | GRM2TAAR1MMP2MMP9MMP8 | |
| SCHEMBL14890375 | 0.82 | GRM2 (0.42) | GRM2TAAR1MMP2MMP9MMP8 | |
| SCHEMBL14919044 | 0.82 | GRM2 (0.42) | GRM2TAAR1MMP2MMP9MMP8 | |
| SCHEMBL18691797 | 0.82 | GRM2 (0.42) | GRM2TAAR1MMP2MMP9MMP8 | |
| SCHEMBL18724666 | 0.78 | POLB (0.34) | RIPK1 | |
| SCHEMBL22639146 | 0.77 | GRM2 (0.41) | GRM2TAAR1MMP2MMP9MMP8 | |
| SCHEMBL21310317 | 0.77 | GRM2 (0.40) | GRM2TAAR1MMP2MMP9MMP8 | |
| SCHEMBL1231214 | 0.77 | RIPK1 (0.38) | RIPK1MMEACE | |
| SCHEMBL1231216 | 0.77 | RIPK1 (0.38) | RIPK1MMEACE | |
| SCHEMBL8012442 | 0.75 | RIPK1 (0.37) | RIPK1MMEACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3199517-A1 | NEPRILYSIN INHIBITORS | Theravance Biopharma R&D IP, LLC (US) | 2017-08-02 | — | — | EP | disclosed |