Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 10/20 | 0.70 |
| ▸ | FPR2 | P25090 | 8/20 | 0.70 |
| ▸ | IDO1 | P14902 | 6/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19192366 | 0.86 | FPR2 (0.76) | GRM5FPR2NPC1RAB9A | |
| SCHEMBL19192151 | 0.86 | FPR2 (0.76) | GRM5FPR2NPC1RAB9A | |
| SCHEMBL11027368 | 0.84 | GRM5 (0.66) | GRM5FPR2IDO1L3MBTL1 | |
| SCHEMBL9960986 | 0.84 | GRM5 (0.62) | GRM5FPR2IDO1TP53L3MBTL1 | |
| SCHEMBL11028972 | 0.84 | GRM5 (0.62) | GRM5FPR2IDO1TP53L3MBTL1 | |
| SCHEMBL11028870 | 0.84 | GRM5 (0.62) | GRM5FPR2IDO1TP53L3MBTL1 | |
| SCHEMBL11030302 | 0.83 | GRM5 (0.67) | GRM5FPR2IDO1TP53 | |
| SCHEMBL19192385 | 0.83 | GRM5 (1.00) | GRM5FPR2IDO1 | |
| SCHEMBL10151943 | 0.83 | GRM5 (1.00) | GRM5FPR2IDO1 | |
| SCHEMBL11029977 | 0.82 | GRM5 (0.73) | GRM5FPR2IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2654422-B1 | Bicyclo[3.2.1]octyl amide derivatives as allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5 or mGluR5) for the treatment of central nervous system (CNS) disorders | H LUNDBECK AS (DK) | 2017-08-02 | — | — | EP | disclosed |