SCHEMBL19192578

SCHEMBL19192578

Cc1cc(-c2cccc(O)c2)n(-c2ccccc2)n1

nearest known ligand 0.73

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 1/20 0.73
RAB9A P51151 1/20 0.73
ALDH1A1 P00352 4/20 0.57
HPGD P15428 3/20 0.57
ALOX5 P09917 1/20 0.55
PTGS2 P35354 2/20 0.53
FCGR1A P12314 1/20 0.51
MAPT P10636 2/20 0.51
KDM4E B2RXH2 1/20 0.51
HSD17B10 Q99714 1/20 0.51
CYP2C19 P33261 3/20 0.51
CYP1A2 P05177 2/20 0.51
CYP2C9 P11712 2/20 0.51
RECQL P46063 1/20 0.51
MGLL Q99685 1/20 0.49
MAPK1 P28482 2/20 0.49
RPA1 P27694 2/20 0.48
NR3C2 P08235 1/20 0.47
SLC5A1 P13866 1/20 0.47
NTRK1 P04629 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10645870 0.85 NPC1 (1.00) NPC1RAB9AALDH1A1HPGDALOX5
SCHEMBL11382119 0.84 NPC1 (0.78) NPC1RAB9AALDH1A1HPGDALOX5
SCHEMBL12361461 0.82 NPC1 (0.93) NPC1RAB9AALDH1A1HPGDALOX5
SCHEMBL21254105 0.79 NPC1 (0.69) NPC1RAB9AALDH1A1HPGDALOX5
SCHEMBL20239624 0.79 RAB9A (0.69) NPC1RAB9AALDH1A1HPGDALOX5
SCHEMBL12361454 0.78 NPC1 (0.77) NPC1RAB9AALDH1A1HPGDALOX5
SCHEMBL10194259 0.78 NPC1 (0.83) NPC1RAB9AALDH1A1HPGDALOX5
SCHEMBL16139661 0.77 NPC1 (0.66) NPC1RAB9AALDH1A1HPGDALOX5
SCHEMBL27882807 0.77 RAB9A (0.71) NPC1RAB9AALDH1A1HPGDALOX5
SCHEMBL23398739 0.76 RPA1 (0.57) NPC1RAB9AALDH1A1HPGDPTGS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3199533-A1 PYRAZOLE COMPOUND AND PHARMACEUTICAL USE THEREOF Japan Tobacco Inc. (JP) 2017-08-02 EP disclosed