Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 6/20 | 0.44 |
| ▸ | PRCP | P42785 | 12/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.39 |
| ▸ | MC3R | P41968 | 3/20 | 0.39 |
| ▸ | MC5R | P33032 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13493146 | 1.00 | MC4R (0.44) | MC4RPRCPNTRK1MC3RMC5R | |
| SCHEMBL12536408 | 1.00 | MC4R (0.44) | MC4RPRCPNTRK1MC3RMC5R | |
| SCHEMBL12536508 | 1.00 | MC4R (0.44) | MC4RPRCPNTRK1MC3RMC5R | |
| SCHEMBL1919871 | 0.93 | MC4R (0.40) | MC4RPRCPNTRK1MC3RMC5R | |
| SCHEMBL1919873 | 0.93 | MC4R (0.40) | MC4RPRCPNTRK1MC3RMC5R | |
| SCHEMBL12536723 | 0.93 | MC4R (0.40) | MC4RPRCPNTRK1MC3RMC5R | |
| SCHEMBL12536731 | 0.93 | MC4R (0.40) | MC4RPRCPNTRK1MC3RMC5R | |
| SCHEMBL15039673 | 0.93 | MC4R (0.44) | MC4RPRCPNTRK1MC3RMC5R | |
| SCHEMBL1919618 | 0.92 | MC4R (0.44) | MC4RPRCPMC3RMC5RKCNH2 | |
| SCHEMBL12536329 | 0.92 | MC4R (0.45) | MC4RPRCPMC3RMC5RKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8592403-B2 | Diazepine and diazocane compounds as MC4 agonists | PFIZER LIMITED (GB) | 2013-11-26 | — | — | US | claimed |
| EP-2326638-B9 | DIAZEPINE AND DIAZOCANE COMPOUNDS AS MC4 AGONISTS | PFIZER LTD (GB) | 2013-11-13 | — | — | EP | claimed |
| EP-2326638-B1 | DIAZEPINE AND DIAZOCANE COMPOUNDS AS MC4 AGONISTS | PFIZER LTD (GB) | 2013-06-19 | — | — | EP | claimed |
| JP-2011529959-A | — | — | 2011-12-15 | — | — | JP | claimed |
| US-20110136814-A1 | Diazepine and Diazocane Compounds As MC4 Agonists | ANDREWS MARK DAVID | 2011-06-09 | — | — | US | claimed |
| EP-2326638-A1 | DIAZEPINE AND DIAZOCANE COMPOUNDS AS MC4 AGONISTS | Pfizer Limited (GB) | 2011-06-01 | — | — | EP | claimed |
| WO-2010015972-A1 | DIAZEPINE AND DIAZOCANE COMPOUNDS AS MC4 AGONISTS | PFIZER LIMITED (GB) | 2010-02-11 | — | — | WO | claimed |
| US-8592403-B2 | Diazepine and diazocane compounds as MC4 agonists | PFIZER LIMITED (GB) | 2013-11-26 | — | — | US | disclosed |
| US-20110136814-A1 | Diazepine and Diazocane Compounds As MC4 Agonists | ANDREWS MARK DAVID | 2011-06-09 | — | — | US | disclosed |
| US-20110136814-A1 | Diazepine and Diazocane Compounds As MC4 Agonists | ANDREWS MARK DAVID | 2011-06-09 | — | — | US | disclosed |
| US-20110136814-A1 | Diazepine and Diazocane Compounds As MC4 Agonists | ANDREWS MARK DAVID | 2011-06-09 | — | — | US | disclosed |
| EP-2326638-A1 | DIAZEPINE AND DIAZOCANE COMPOUNDS AS MC4 AGONISTS | Pfizer Limited (GB) | 2011-06-01 | — | — | EP | disclosed |
| WO-2010015972-A1 | DIAZEPINE AND DIAZOCANE COMPOUNDS AS MC4 AGONISTS | PFIZER LIMITED (GB) | 2010-02-11 | — | — | WO | disclosed |
| WO-2010015972-A1 | DIAZEPINE AND DIAZOCANE COMPOUNDS AS MC4 AGONISTS | PFIZER LIMITED (GB) | 2010-02-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110136814-A1 | Diazepine and Diazocane Compounds As MC4 Agonists | MC4R, CHRM4, GPR4 | MC4R 1/4885PRCP 2814/4885NTRK1 766/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.