Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 13/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 11/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 10/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NCOR2 | Q9Y618 | 4/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 4/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL197315 | 0.92 | GRM5 (0.46) | HDAC1HDAC2HDAC3MAPK1NCOR2 | |
| SCHEMBL1920008 | 0.90 | HDAC1 (0.43) | HDAC1HDAC2HDAC3MAPK1NCOR2 | |
| SCHEMBL197818 | 0.89 | F10 (0.49) | HDAC1HDAC2HDAC3HDAC6HDAC4 | |
| SCHEMBL196803 | 0.88 | HDAC2 (0.44) | HDAC1HDAC2HDAC3HDAC6HDAC4 | |
| SCHEMBL196499 | 0.88 | HDAC1 (0.40) | HDAC1HDAC2HDAC3NCOR2HDAC6 | |
| SCHEMBL198643 | 0.88 | GRAMD1A (0.53) | HDAC1 | |
| SCHEMBL196500 | 0.88 | HDAC1 (0.40) | HDAC1HDAC2HDAC3NCOR2HDAC6 | |
| SCHEMBL197423 | 0.87 | HDAC1 (0.45) | HDAC1HDAC2HDAC3HDAC6HDAC4 | |
| SCHEMBL197962 | 0.86 | KMT2A (0.45) | HDAC1HDAC2HDAC3NCOR2HDAC6 | |
| SCHEMBL196952 | 0.84 | HDAC1 (0.44) | HDAC1HDAC2HDAC3MAPK1NCOR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2326622-A1 | CYCLOALKYLIDENE AND HETEROCYCLOALKYLIDENE HISTONE DEACETYLASE INHIBITOR COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2011-06-01 | — | — | EP | disclosed |
| WO-2010014611-A1 | CYCLOALKYLIDENE AND HETEROCYCLOALKYLIDENE HISTONE DEACETYLASE INHIBITOR COMPOUNDS | GILEAD COLORADO, INC. (US) | 2010-02-04 | — | — | WO | disclosed |