Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 17/20 | 0.56 |
| ▸ | EGFR | P00533 | 9/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.51 |
| ▸ | TGM2 | P21980 | 1/20 | 0.49 |
| ▸ | JAK3 | P52333 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16597876 | 0.82 | BTK (0.61) | BTKEGFRKCNH2ERBB2TGM2 | |
| SCHEMBL19202348 | 0.80 | BTK (0.54) | BTKEGFRKCNH2ERBB2TGM2 | |
| SCHEMBL16671074 | 0.75 | BTK (0.59) | BTKEGFRKCNH2ERBB2TGM2 | |
| SCHEMBL16676616 | 0.75 | BTK (0.55) | BTKEGFRKCNH2ERBB2TGM2 | |
| SCHEMBL14165280 | 0.73 | BTK (0.63) | BTKEGFRKCNH2ERBB2TGM2 | |
| SCHEMBL22732031 | 0.73 | TGM2 (0.74) | BTKEGFRKCNH2ERBB2TGM2 | |
| SCHEMBL18800803 | 0.72 | SCN9A (0.48) | BTK | |
| SCHEMBL14165518 | 0.72 | BTK (0.87) | BTKEGFRKCNH2ERBB2TGM2 | |
| SCHEMBL30695683 | 0.72 | BTK (0.87) | BTKEGFRKCNH2ERBB2TGM2 | |
| SCHEMBL14165528 | 0.72 | BTK (0.87) | BTKEGFRKCNH2ERBB2TGM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3409672-B1 | PARAZOLE CONDENSED-RING DERIVATIVES AND PREPARATION METHOD THEREOF AND APPLICATION THEREOF IN TREATMENT OF CANCERS, INFLAMMATION AND IMMUNE DISEASES | BEIJING INNOCARE PHARMA TECH CO LTD (CN) | 2021-12-08 | — | — | EP | disclosed |
| WO-2017128917-A1 | PARAZOLE CONDENSED-RING DERIVATIVES AND PREPARATION METHOD THEREOF AND APPLICATION THEREOF IN TREATMENT OF CANCERS, INFLAMMATION AND IMMUNE DISEASES | 北京诺诚健华医药科技有限公司 | 2017-08-03 | — | — | WO | disclosed |