Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 20/20 | 0.70 |
| ▸ | EGFR | P00533 | 2/20 | 0.54 |
| ▸ | ITK | Q08881 | 2/20 | 0.54 |
| ▸ | LCK | P06239 | 1/20 | 0.54 |
| ▸ | BMX | P51813 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19202379 | 0.86 | BTK (0.51) | BTKEGFRITKLCKBMX | |
| SCHEMBL19202583 | 0.85 | BTK (0.70) | BTKEGFRITKLCKBMX | |
| SCHEMBL19202397 | 0.83 | BTK (0.64) | BTKEGFRITKBMX | |
| SCHEMBL19203239 | 0.83 | BTK (0.64) | BTKEGFRITKBMX | |
| SCHEMBL19202649 | 0.83 | BTK (1.00) | BTKEGFRITKLCKBMX | |
| SCHEMBL24083380 | 0.80 | BTK (0.71) | BTKEGFRITKBMX | |
| SCHEMBL24083387 | 0.79 | BTK (0.46) | BTKEGFRLCK | |
| SCHEMBL19202565 | 0.79 | BTK (0.68) | BTKEGFRITKBMX | |
| SCHEMBL19203232 | 0.78 | BTK (0.50) | BTKEGFRITKLCKBMX | |
| SCHEMBL24083383 | 0.78 | BTK (0.53) | BTKEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3409672-B1 | PARAZOLE CONDENSED-RING DERIVATIVES AND PREPARATION METHOD THEREOF AND APPLICATION THEREOF IN TREATMENT OF CANCERS, INFLAMMATION AND IMMUNE DISEASES | BEIJING INNOCARE PHARMA TECH CO LTD (CN) | 2021-12-08 | — | — | EP | disclosed |
| WO-2017128917-A1 | PARAZOLE CONDENSED-RING DERIVATIVES AND PREPARATION METHOD THEREOF AND APPLICATION THEREOF IN TREATMENT OF CANCERS, INFLAMMATION AND IMMUNE DISEASES | 北京诺诚健华医药科技有限公司 | 2017-08-03 | — | — | WO | disclosed |