⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1630772 | 0.79 | NPC1 (0.54) | — | |
| SCHEMBL1395649 | 0.79 | NPC1 (0.54) | — | |
| SCHEMBL1022195 | 0.79 | NPC1 (0.54) | — | |
| SCHEMBL30483744 | 0.78 | CA12 (0.48) | — | |
| SCHEMBL198932 | 0.77 | — | — | |
| SCHEMBL18657110 | 0.76 | NPC1 (0.47) | — | |
| SCHEMBL11607084 | 0.74 | — | — | |
| SCHEMBL22062236 | 0.74 | — | — | |
| SCHEMBL2655451 | 0.74 | — | — | |
| SCHEMBL1132777 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105377835-A | Protein tyrosine kinase modulators and methods of use | ZHEJIANG BETA PHARMA INC | 2016-03-02 | — | — | CN | claimed |
| CN-101044113-A | Substituted indole compounds, their preparation and use in medicaments | ESTEVE LABOR DR (ES) | 2007-09-26 | — | — | CN | claimed |
| CN-1310906-C | Indole-type derivatives as inhibitors of p38 kinase | SCOIS INC (US) | 2007-04-18 | — | — | CN | claimed |
| EP-1717227-A1 | Substituted indole compounds, their preparation and use in medicaments | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2006-11-02 | — | — | EP | claimed |
| WO-2022250069-A1 | SULFUR-CONTAINING PYRAZOLE COMPOUND AND NOXIOUS ORGANISM CONTROL AGENT INCLUDING SULFUR-CONTAINING PYRAZOLE COMPOUND AS ACTIVE INGREDIENT | 三井化学アグロ株式会社 | 2022-12-01 | — | — | WO | disclosed |
| CN-105377835-A | Protein tyrosine kinase modulators and methods of use | ZHEJIANG BETA PHARMA INC | 2016-03-02 | — | — | CN | disclosed |
| EP-2326649-A1 | NOVEL PYRROLO Ý2,3-A¨CARBAZOLES AND USE THEREOF AS PIM KINASE INHIBITORS | Centre National de la Recherche Scientifique (FR) | 2011-06-01 | — | — | EP | disclosed |
| WO-2010000978-A1 | NOVEL PYRROLO [2,3-A] CARBAZOLES AND USE THEREOF AS PIM KINASE INHIBITORS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2010-01-07 | — | — | WO | disclosed |
| CN-101563106-A | Combination of nmda- receptor ligand and a compound with 5-HT6 receptor affinity | ESTEVE LABOR DR (ES) | 2009-10-21 | — | — | CN | disclosed |
| CN-101500611-A | Combination of a cholinesterase inhibitor and a compound with 5-HT6 receptor affinity | ESTEVE LABOR DR (ES) | 2009-08-05 | — | — | CN | disclosed |
| EP-2081600-A1 | COMBINATION OF NMDA- RECEPTOR LIGAND AND A COMPOUND WITH 5-HT6 RECEPTOR AFFINITY | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2009-07-29 | — | — | EP | disclosed |
| EP-2018861-A1 | 5HT6-Ligands such as sulfonamide derivatives in drug-induced weight-gain | Laboratorios del Dr. Esteve S.A. (ES) | 2009-01-28 | — | — | EP | disclosed |
| EP-1717227-A1 | Substituted indole compounds, their preparation and use in medicaments | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2006-11-02 | — | — | EP | disclosed |
| EP-0510068-B1 | NEW CENTRALLY ACTING 6,7,8,9-TETRAHYDRO-3H-BENZ(e)INDOLE HETEROCYCLICS | UPJOHN CO (US) | 1999-04-14 | — | — | EP | disclosed |
| US-5650427-A | ANTIDEPRESSANTS | THE UPJOHN COMPANY (US) | 1997-07-22 | — | — | US | disclosed |
| US-5461061-A | Antidepressants | WIKSTROM HAKAN V (NL) | 1995-10-24 | — | — | US | disclosed |
| US-5288748-A | Antidepressants | THE UPJOHN COMPANY (US) | 1994-02-22 | — | — | US | disclosed |
| EP-0510068-A1 | NEW CENTRALLY ACTING 6,7,8,9-TETRAHYDRO-3H-BENZ(e)INDOLE HETEROCYCLICS | PHARMACIA & UPJOHN COMPANY (US) | 1992-10-28 | — | — | EP | disclosed |
| WO-1991011435-A2 | NEW CENTRALLY ACTING 6,7,8,9-TETRAHYDRO-3H-BENZ(e)INDOLE HETEROCYCLICS | THE UPJOHN COMPANY (US) | 1991-08-08 | — | — | WO | disclosed |
| US-4067724-A | N-(1,2,4-Triazin-5-on-4-yl)-glycines and herbicidal compositions | BAYER AKTIENGESELLSCHAFT (DT) | 1978-01-10 | — | — | US | disclosed |