Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F11 | P03951 | 20/20 | 0.56 |
| ▸ | KLKB1 | P03952 | 6/20 | 0.56 |
| ▸ | PLAT | P00750 | 4/20 | 0.54 |
| ▸ | KLK1 | P06870 | 1/20 | 0.54 |
| ▸ | F10 | P00742 | 4/20 | 0.45 |
| ▸ | F9 | P00740 | 2/20 | 0.42 |
| ▸ | PLG | P00747 | 3/20 | 0.42 |
| ▸ | PROC | P04070 | 2/20 | 0.42 |
| ▸ | F2 | P00734 | 1/20 | 0.42 |
| ▸ | PLAU | P00749 | 1/20 | 0.42 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.42 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.42 |
| ▸ | F7 | P08709 | 1/20 | 0.42 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1921238 | 0.93 | F11 (0.58) | F11KLKB1PLATKLK1F10 | |
| SCHEMBL1196214 | 0.90 | F11 (0.57) | F11KLKB1PLATKLK1F10 | |
| SCHEMBL1196216 | 0.90 | F11 (0.57) | F11KLKB1PLATKLK1F10 | |
| SCHEMBL1197685 | 0.88 | F11 (0.59) | F11KLKB1PLATKLK1F10 | |
| SCHEMBL1197683 | 0.88 | F11 (0.59) | F11KLKB1PLATKLK1F10 | |
| SCHEMBL1921226 | 0.88 | F11 (0.74) | F11KLKB1PLATF10F9 | |
| SCHEMBL1920396 | 0.87 | F11 (0.73) | F11KLKB1PLATKLK1F10 | |
| SCHEMBL1197118 | 0.84 | F11 (0.74) | F11KLKB1PLATKLK1F10 | |
| SCHEMBL1197119 | 0.84 | F11 (0.74) | F11KLKB1PLATKLK1F10 | |
| SCHEMBL1920923 | 0.81 | F11 (0.78) | F11KLKB1PLATF10F9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981854-B1 | ARYLPROPIONAMIDE, ARYLACRYLAMIDE, ARYLPROPYNAMIDE, OR ARYLMETHYLUREA ANALOGS AS FACTOR XIA INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2011-06-01 | — | — | EP | claimed |