Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.64 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.64 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.64 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.64 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.64 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.64 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.64 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.64 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.64 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.64 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | CES1 | P23141 | 1/20 | 0.57 |
| ▸ | PGR | P06401 | 9/20 | 0.56 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4063073 | 0.86 | HDAC2 (0.62) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL29047616 | 0.85 | CYP19A1 (0.73) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL28380387 | 0.85 | PGR (0.51) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL15652924 | 0.85 | HDAC1 (0.64) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL29571412 | 0.85 | PGR (0.51) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL15652958 | 0.81 | KMT2A (0.60) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL13762642 | 0.81 | HDAC1 (0.78) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL13762641 | 0.81 | HDAC1 (0.78) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL28406134 | 0.81 | CES1 (0.76) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL29549842 | 0.81 | CES1 (0.76) | HDAC3HDAC4HDAC1HDAC7HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245006-B1 | SULFONAMIDES AS OREXIN ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2011-06-01 | — | — | EP | disclosed |