SCHEMBL19204937

SCHEMBL19204937

O=[N+]([O-])c1ccc([N+](=O)[O-])c(C2CC2)c1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 1/20 0.57
GPR35 Q9HC97 2/20 0.52
CHRNB4 P30926 3/20 0.50
CHRNA3 P32297 3/20 0.50
TDP1 Q9NUW8 3/20 0.48
SLC18A3 Q16572 1/20 0.48
TSHR P16473 4/20 0.47
ALDH1A1 P00352 3/20 0.47
HIF1A Q16665 2/20 0.47
MAPK1 P28482 2/20 0.47
TP53 P04637 1/20 0.47
HPGD P15428 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.47
TXNRD1 Q16881 1/20 0.46
TXNRD3 Q86VQ6 1/20 0.46
TXNRD2 Q9NNW7 1/20 0.46
NOS3 P29474 1/20 0.43
NOS1 P29475 1/20 0.43
NOS2 P35228 1/20 0.43
CHRNB2 P17787 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6903614 0.91 HSP90AA1 (0.69) HSP90AA1GPR35CHRNB4CHRNA3TDP1
SCHEMBL28092025 0.85 CHRNB4 (0.67) HSP90AA1CHRNB4CHRNA3TDP1SLC18A3
SCHEMBL12825154 0.81 HSP90AA1 (0.57) HSP90AA1CHRNB4CHRNA3TDP1TSHR
SCHEMBL1531296 0.80 HSP90AA1 (0.84) HSP90AA1GPR35CHRNB4CHRNA3TDP1
SCHEMBL16958047 0.80 TSHR (0.58) GPR35TDP1TSHRALDH1A1MAPK1
SCHEMBL22230552 0.80 HSP90AA1 (0.55) HSP90AA1CHRNB4CHRNA3SLC18A3TSHR
SCHEMBL30411115 0.80 TDP1 (0.56) HSP90AA1CHRNB4CHRNA3TDP1SLC18A3
SCHEMBL16958044 0.80 TSHR (0.39) HSP90AA1GPR35TDP1SLC18A3TSHR
SCHEMBL19180312 0.80 TDP1 (0.56) HSP90AA1CHRNB4CHRNA3TDP1SLC18A3
SCHEMBL28092024 0.80 S100A4 (0.41) HSP90AA1GPR35TDP1SLC18A3TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9732070-B2 Protein kinase C inhibitors and uses thereof RIGEL PHARMACEUTICALS, INC. (US) 2017-08-15 US disclosed