Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | TBXAS1 | P24557 | 5/20 | 0.42 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KCNH3 | Q9ULD8 | 1/20 | 0.33 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | FRK | P42685 | 1/20 | 0.33 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.33 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.33 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 1,6-Hexanediol SCHEMBL11582636 | 1.00 | TSHR (0.53) | TSHRNAPRTTDP1TBXAS1GPR84 | |
| Octanol SCHEMBL28192502 | 0.88 | LMNA (0.59) | TSHRNAPRTTDP1TBXAS1LMNA | |
| Pyridine SCHEMBL27488003 | 0.88 | LMNA (0.59) | TSHRNAPRTTDP1TBXAS1LMNA | |
| Cetyl Alcohol SCHEMBL6680914 | 0.88 | LMNA (0.59) | TSHRNAPRTTDP1TBXAS1LMNA | |
| Dodecanol SCHEMBL9146033 | 0.88 | LMNA (0.59) | TSHRNAPRTTDP1TBXAS1LMNA | |
| 1-Hexanol SCHEMBL10425295 | 0.88 | LMNA (0.59) | TSHRNAPRTTDP1TBXAS1LMNA | |
| 1-Hexanol SCHEMBL8608061 | 0.86 | LMNA (0.56) | TSHRNAPRTTDP1TBXAS1LMNA | |
| Cetostearyl Alcohol SCHEMBL28002648 | 0.86 | LMNA (0.56) | TSHRNAPRTTDP1TBXAS1LMNA | |
| 1-Pentanol SCHEMBL27902508 | 0.85 | SMN1; SMN2 (0.57) | TSHRNAPRTTDP1TBXAS1LMNA | |
| Pyridine SCHEMBL4592912 | 0.84 | TSHR (0.64) | TSHRNAPRTTDP1ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2326331-A1 | NOVEL LIPID NANOPARTICLES AND NOVEL COMPONENTS FOR DELIVERY OF NUCLEIC ACIDS | Merck Sharp & Dohme Corp. (US) | 2011-06-01 | — | — | EP | disclosed |
| WO-2010021865-A1 | NOVEL LIPID NANOPARTICLES AND NOVEL COMPONENTS FOR DELIVERY OF NUCLEIC ACIDS | MERCK SHARP & DOHME CORP. (US) | 2010-02-25 | — | — | WO | disclosed |