Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | PYGL | P06737 | 2/20 | 0.44 |
| ▸ | PYGM | P11217 | 2/20 | 0.44 |
| ▸ | CCKBR | P32239 | 10/20 | 0.44 |
| ▸ | CCKAR | P32238 | 1/20 | 0.43 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.42 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.42 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.42 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.42 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.42 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19207822 | 0.83 | SCN9A (0.47) | CCKBRCCKAR | |
| SCHEMBL7819630 | 0.83 | SCN9A (0.47) | CCKBRCCKAR | |
| SCHEMBL15964676 | 0.82 | SCN9A (0.50) | RIPK1ALDH1A1 | |
| SCHEMBL15956793 | 0.77 | RIPK1 (0.57) | RIPK1PYGLPYGMCCKBR | |
| SCHEMBL5396473 | 0.76 | RIPK1 (0.48) | RIPK1PYGLPYGMCCKBR | |
| SCHEMBL17321316 | 0.76 | RIPK1 (0.83) | RIPK1 | |
| SCHEMBL3924251 | 0.75 | RIPK1 (0.63) | RIPK1PYGLPYGMCCKBRPSEN1 | |
| SCHEMBL4218830 | 0.75 | RIPK1 (0.63) | RIPK1PYGLPYGMCCKBRPSEN1 | |
| SCHEMBL4852198 | 0.74 | PSEN1 (0.43) | KDM4EALDH1A1HPGDCCKBRCCKAR | |
| SCHEMBL4191956 | 0.74 | RIPK1 (0.60) | RIPK1PYGLPYGM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3414239-A2 | INHIBITORS OF RECEPTOR-INTERACTING PROTEIN KINASE 1 | Denali Therapeutics Inc. (US) | 2018-12-19 | — | — | EP | disclosed |
| WO-2017136727-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | DENALI THERAPEUTICS INC. (US) | 2017-08-10 | — | — | WO | disclosed |