Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 20/20 | 1.00 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19207725 | 1.00 | RIPK1 (1.00) | RIPK1NR1I2CYP2C9 | |
| SCHEMBL29415766 | 0.88 | RIPK1 (1.00) | RIPK1 | |
| SCHEMBL19207576 | 0.88 | RIPK1 (1.00) | RIPK1 | |
| SCHEMBL19207579 | 0.88 | RIPK1 (1.00) | RIPK1 | |
| SCHEMBL19207810 | 0.88 | RIPK1 (1.00) | RIPK1 | |
| SCHEMBL19207806 | 0.88 | RIPK1 (1.00) | RIPK1 | |
| SCHEMBL20904027 | 0.86 | RIPK1 (0.78) | RIPK1NR1I2CYP2C9 | |
| SCHEMBL17312701 | 0.85 | RIPK1 (0.73) | RIPK1NR1I2CYP2C9 | |
| SCHEMBL17312704 | 0.85 | RIPK1 (0.73) | RIPK1NR1I2CYP2C9 | |
| SCHEMBL19866126 | 0.83 | RIPK1 (0.71) | RIPK1NR1I2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3414239-A2 | INHIBITORS OF RECEPTOR-INTERACTING PROTEIN KINASE 1 | Denali Therapeutics Inc. (US) | 2018-12-19 | — | — | EP | disclosed |
| WO-2017136727-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | DENALI THERAPEUTICS INC. (US) | 2017-08-10 | — | — | WO | disclosed |
| WO-2017136727-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | DENALI THERAPEUTICS INC. (US) | 2017-08-10 | — | — | WO | disclosed |