Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 20/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19207736 | 1.00 | RIPK1 (1.00) | RIPK1 | |
| SCHEMBL19207542 | 0.91 | RIPK1 (1.00) | RIPK1 | |
| SCHEMBL19207543 | 0.91 | RIPK1 (1.00) | RIPK1 | |
| SCHEMBL19207781 | 0.91 | RIPK1 (1.00) | RIPK1 | |
| SCHEMBL19207777 | 0.91 | RIPK1 (1.00) | RIPK1 | |
| SCHEMBL19224722 | 0.90 | RIPK1 (0.91) | RIPK1 | |
| SCHEMBL19207767 | 0.88 | RIPK1 (1.00) | RIPK1 | |
| SCHEMBL19207762 | 0.88 | RIPK1 (1.00) | RIPK1 | |
| SCHEMBL19207811 | 0.88 | RIPK1 (1.00) | RIPK1 | |
| SCHEMBL19207809 | 0.88 | RIPK1 (1.00) | RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3414239-A2 | INHIBITORS OF RECEPTOR-INTERACTING PROTEIN KINASE 1 | Denali Therapeutics Inc. (US) | 2018-12-19 | — | — | EP | disclosed |
| WO-2017136727-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | DENALI THERAPEUTICS INC. (US) | 2017-08-10 | — | — | WO | disclosed |