Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 20/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19207881 | 1.00 | RIPK1 (0.65) | RIPK1 | |
| SCHEMBL3910591 | 0.89 | RIPK1 (0.68) | RIPK1 | |
| SCHEMBL3910585 | 0.89 | RIPK1 (0.68) | RIPK1 | |
| SCHEMBL31656042 | 0.87 | RIPK1 (0.64) | RIPK1 | |
| SCHEMBL19255334 | 0.83 | RIPK1 (0.57) | RIPK1 | |
| SCHEMBL12345835 | 0.83 | RIPK1 (0.58) | RIPK1 | |
| SCHEMBL31655905 | 0.83 | RIPK1 (0.60) | RIPK1 | |
| SCHEMBL14386223 | 0.83 | RIPK1 (0.58) | RIPK1 | |
| SCHEMBL20904076 | 0.80 | RIPK1 (0.55) | RIPK1 | |
| SCHEMBL31655944 | 0.80 | RIPK1 (0.65) | RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3414239-A2 | INHIBITORS OF RECEPTOR-INTERACTING PROTEIN KINASE 1 | Denali Therapeutics Inc. (US) | 2018-12-19 | — | — | EP | disclosed |
| US-9896458-B2 | Compounds, compositions and methods | DENALI THERAPEUTICS INC. (US) | 2018-02-20 | — | — | US | disclosed |
| WO-2017136727-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | DENALI THERAPEUTICS INC. (US) | 2017-08-10 | — | — | WO | disclosed |
| WO-2017136727-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | DENALI THERAPEUTICS INC. (US) | 2017-08-10 | — | — | WO | disclosed |