Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F11 | P03951 | 16/20 | 0.39 |
| ▸ | KLKB1 | P03952 | 4/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.34 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.34 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.34 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.34 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
| ▸ | PLG | P00747 | 1/20 | 0.34 |
| ▸ | F12 | P00748 | 1/20 | 0.34 |
| ▸ | KLK1 | P06870 | 1/20 | 0.34 |
| ▸ | F7 | P08709 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1196071 | 0.91 | F11 (0.48) | F11KLKB1 | |
| SCHEMBL1196623 | 0.76 | F11 (0.52) | F11KLKB1 | |
| SCHEMBL1196835 | 0.75 | F11 (0.46) | F11KLKB1 | |
| SCHEMBL1196839 | 0.75 | F11 (0.46) | F11KLKB1 | |
| SCHEMBL1197333 | 0.72 | F11 (0.63) | F11KLKB1ROCK2PRSS1PRSS2 | |
| SCHEMBL1197057 | 0.72 | F11 (0.63) | F11KLKB1ROCK2PRSS1PRSS2 | |
| SCHEMBL1197359 | 0.71 | F11 (0.55) | F11KLKB1 | |
| SCHEMBL1197356 | 0.71 | F11 (0.55) | F11KLKB1 | |
| SCHEMBL1196551 | 0.69 | F11 (0.57) | F11KLKB1ROCK2PRSS1PRSS2 | |
| SCHEMBL1196478 | 0.67 | F11 (0.52) | F11KLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981854-B1 | ARYLPROPIONAMIDE, ARYLACRYLAMIDE, ARYLPROPYNAMIDE, OR ARYLMETHYLUREA ANALOGS AS FACTOR XIA INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2011-06-01 | — | — | EP | disclosed |
| EP-1981854-A1 | ARYLPROPIONAMIDE, ARYLACRYLAMIDE, ARYLPROPYNAMIDE, OR ARYLMETHYLUREA ANALOGS AS FACTOR XIA INHIBITORS | Brystol-Myers Squibb Company (US) | 2008-10-22 | — | — | EP | disclosed |
| WO-2007070826-A1 | ARYLPROPIONAMIDE, ARYLACRYLAMIDE, ARYLPROPYNAMIDE, OR ARYLMETHYLUREA ANALOGS AS FACTOR XIA INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-06-21 | — | — | WO | disclosed |