Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A1 | P18405 | 3/20 | 0.43 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.41 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.41 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.41 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.41 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.38 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.38 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.37 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.36 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31347608 | 0.91 | SRD5A1 (0.51) | SRD5A1HDAC1HDAC8HDAC6CYP11B2 | |
| SCHEMBL30832131 | 0.89 | BMPR1B (0.49) | SRD5A1BMPR1BBMPR1ATGFBR1ACVRL1 | |
| SCHEMBL19224681 | 0.89 | BMPR1B (0.49) | SRD5A1BMPR1BBMPR1ATGFBR1ACVRL1 | |
| SCHEMBL265640 | 0.79 | SRD5A1 (0.59) | SRD5A1HDAC1HDAC8HDAC6CYP11B2 | |
| SCHEMBL19207557 | 0.78 | ROCK1 (0.40) | BMPR1BBMPR1ATGFBR1ACVRL1ACVR1 | |
| SCHEMBL31559514 | 0.78 | SRD5A1 (0.48) | SRD5A1HDAC1HDAC8HDAC6CYP1A2 | |
| SCHEMBL30832142 | 0.76 | SRD5A1 (0.46) | SRD5A1BMPR1BBMPR1ATGFBR1ACVRL1 | |
| SCHEMBL22290609 | 0.76 | SRD5A1 (0.46) | SRD5A1BMPR1BBMPR1ATGFBR1ACVRL1 | |
| SCHEMBL21173084 | 0.75 | SRD5A1 (0.48) | SRD5A1BMPR1BBMPR1ATGFBR1ACVRL1 | |
| SCHEMBL21042109 | 0.74 | HDAC1 (0.39) | SRD5A1BMPR1BBMPR1ATGFBR1ACVRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114437105-A | Inhibitors of receptor interacting protein kinase 1 | 戴纳立制药公司 | 2022-05-06 | — | — | CN | disclosed |
| CN-109071504-B | Inhibitors of receptor interacting protein kinase 1 | 戴纳立制药公司 | 2022-03-08 | — | — | CN | disclosed |
| EP-3414239-A2 | INHIBITORS OF RECEPTOR-INTERACTING PROTEIN KINASE 1 | Denali Therapeutics Inc. (US) | 2018-12-19 | — | — | EP | disclosed |
| WO-2017136727-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | DENALI THERAPEUTICS INC. (US) | 2017-08-10 | — | — | WO | disclosed |