Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F11 | P03951 | 16/20 | 0.62 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.45 |
| ▸ | PLAT | P00750 | 1/20 | 0.42 |
| ▸ | KLK1 | P06870 | 1/20 | 0.42 |
| ▸ | F2 | P00734 | 4/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12011704 | 0.91 | F11 (0.65) | F11KLKB1PLATKLK1F2 | |
| SCHEMBL1197646 | 0.88 | F11 (0.79) | F11KLKB1PLAT | |
| SCHEMBL1197645 | 0.88 | F11 (0.79) | F11KLKB1PLAT | |
| SCHEMBL12011687 | 0.80 | F11 (0.82) | F11KLKB1PLATKLK1F2 | |
| SCHEMBL12011707 | 0.79 | F11 (0.63) | F11KLKB1PLATKLK1F2 | |
| SCHEMBL1196587 | 0.78 | F11 (0.79) | F11KLKB1PLAT | |
| SCHEMBL1197275 | 0.78 | F11 (0.74) | F11KLKB1PLATKLK1 | |
| SCHEMBL12011714 | 0.78 | F11 (0.74) | F11KLKB1PLATKLK1F2 | |
| SCHEMBL12011710 | 0.77 | F11 (0.69) | F11KLKB1PLATKLK1F2 | |
| SCHEMBL1196905 | 0.77 | F11 (0.77) | F11KLKB1PLATKLK1F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981854-B1 | ARYLPROPIONAMIDE, ARYLACRYLAMIDE, ARYLPROPYNAMIDE, OR ARYLMETHYLUREA ANALOGS AS FACTOR XIA INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2011-06-01 | — | — | EP | claimed |
| EP-1981854-B1 | ARYLPROPIONAMIDE, ARYLACRYLAMIDE, ARYLPROPYNAMIDE, OR ARYLMETHYLUREA ANALOGS AS FACTOR XIA INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2011-06-01 | — | — | EP | disclosed |