Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F11 | P03951 | 17/20 | 0.47 |
| ▸ | KLKB1 | P03952 | 6/20 | 0.47 |
| ▸ | KLK1 | P06870 | 2/20 | 0.43 |
| ▸ | PLAT | P00750 | 1/20 | 0.43 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.40 |
| ▸ | PRSS2 | P07478 | 4/20 | 0.40 |
| ▸ | PRSS3 | P35030 | 4/20 | 0.40 |
| ▸ | F10 | P00742 | 2/20 | 0.39 |
| ▸ | F12 | P00748 | 2/20 | 0.39 |
| ▸ | F7 | P08709 | 2/20 | 0.39 |
| ▸ | PLG | P00747 | 1/20 | 0.39 |
| ▸ | NOS2 | P35228 | 3/20 | 0.38 |
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
| ▸ | NOS1 | P29475 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1197078 | 0.86 | F11 (0.63) | F11KLKB1PLATF10PLG | |
| SCHEMBL1197080 | 0.86 | F11 (0.63) | F11KLKB1PLATF10PLG | |
| SCHEMBL1197079 | 0.86 | F11 (0.63) | F11KLKB1PLATF10PLG | |
| SCHEMBL1197212 | 0.81 | F11 (0.47) | F11KLKB1KLK1PLATPRSS1 | |
| SCHEMBL1197206 | 0.81 | F11 (0.47) | F11KLKB1KLK1PLATPRSS1 | |
| SCHEMBL1197208 | 0.81 | F11 (0.47) | F11KLKB1KLK1PLATPRSS1 | |
| SCHEMBL1197204 | 0.81 | F11 (0.47) | F11KLKB1KLK1PLATPRSS1 | |
| SCHEMBL1920914 | 0.76 | F11 (0.40) | F11KLKB1KLK1PLATPRSS1 | |
| SCHEMBL1920879 | 0.73 | F11 (0.42) | F11KLKB1KLK1PLATPRSS1 | |
| SCHEMBL1922355 | 0.72 | F11 (0.58) | F11KLKB1KLK1PLATPRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981854-B1 | ARYLPROPIONAMIDE, ARYLACRYLAMIDE, ARYLPROPYNAMIDE, OR ARYLMETHYLUREA ANALOGS AS FACTOR XIA INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2011-06-01 | — | — | EP | claimed |