Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | MEN1 | O00255 | 5/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.49 |
| ▸ | RELA | Q04206 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29781738 | 0.82 | HPGD (0.53) | POLBHPGDALOX15ALDH1A1MEN1 | |
| SCHEMBL20971614 | 0.82 | HPGD (0.53) | POLBHPGDALOX15ALDH1A1MEN1 | |
| SCHEMBL19236692 | 0.82 | HPGD (0.53) | POLBHPGDALOX15ALDH1A1MEN1 | |
| SCHEMBL25371727 | 0.81 | ALDH1A1 (0.69) | POLBALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL25371726 | 0.81 | ALDH1A1 (0.69) | POLBALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL11311282 | 0.80 | MEN1 (0.65) | HPGDALOX15ALDH1A1MEN1KMT2A | |
| SCHEMBL20971627 | 0.78 | HPGD (0.57) | HPGDALOX15ALDH1A1MEN1KMT2A | |
| SCHEMBL19208177 | 0.78 | HPGD (0.57) | HPGDALOX15ALDH1A1MEN1KMT2A | |
| SCHEMBL29781778 | 0.78 | HPGD (0.57) | HPGDALOX15ALDH1A1MEN1KMT2A | |
| SCHEMBL19905657 | 0.77 | MEN1 (0.61) | HPGDALOX15ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3411411-A1 | BENZOPYRAZOLE COMPOUNDS AND ANALOGUES THEREOF | Biocryst Pharmaceuticals, Inc. (US) | 2018-12-12 | — | — | EP | disclosed |
| WO-2017136395-A1 | BENZOPYRAZOLE COMPOUNDS AND ANALOGUES THEREOF | BIOCRYST PHARMACEUTICALS, INC. (US) | 2017-08-10 | — | — | WO | disclosed |