Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 15/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 13/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 8/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20674336 | 0.91 | SLC6A4 (0.35) | SLC6A4SLC6A2SLC6A3CYP2D6KCNH2 | |
| SCHEMBL4914499 | 0.90 | CA14 (0.37) | CA14TDP1HDAC1HDAC2HDAC6 | |
| SCHEMBL6497271 | 0.88 | CA14 (0.36) | CA14TDP1HDAC1HDAC2HDAC6 | |
| SCHEMBL6486782 | 0.87 | CA14 (0.35) | CYP2D6CA14TDP1HDAC1HDAC2 | |
| SCHEMBL6118690 | 0.85 | SLC6A4 (0.45) | SLC6A4SLC6A2SLC6A3CYP2D6KCNH2 | |
| SCHEMBL6485797 | 0.85 | EPHX1 (0.35) | CYP2D6CA14TDP1HDAC1HDAC2 | |
| SCHEMBL4711748 | 0.85 | CA14 (0.39) | CA14TDP1HDAC1HDAC2HDAC6 | |
| SCHEMBL1240735 | 0.84 | CA14 (0.34) | CA14TDP1HDAC1HDAC2HDAC6 | |
| SCHEMBL4658920 | 0.84 | SLC6A4 (0.36) | SLC6A4SLC6A2SLC6A3CYP2D6KCNH2 | |
| SCHEMBL2660428 | 0.84 | CA14 (0.34) | CA14TDP1HDAC1HDAC2HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2326327-A2 | ANALOGS OF INDOLE-3-CARBINOL AND THEIR USE AS AGENTS AGAINST INFECTION | SRI International (US) | 2011-06-01 | — | — | EP | disclosed |
| WO-2010033198-A2 | ANALOGS OF INDOLE-3-CARBINOL AND THEIR USE AS AGENTS AGAINST INFECTION | SRI INTERNATIONAL (US) | 2010-03-25 | — | — | WO | disclosed |