Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK4 | O96013 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.31 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.31 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.31 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.31 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.31 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | FRK | P42685 | 1/20 | 0.31 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.31 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25238260 | 0.82 | SMN1; SMN2 (0.41) | SMN1; SMN2CDK2CSNK1DMAPK11MAPK14 | |
| SCHEMBL30166352 | 0.82 | SMN1; SMN2 (0.41) | SMN1; SMN2CDK2CSNK1DMAPK11MAPK14 | |
| SCHEMBL12413632 | 0.71 | SMN1; SMN2 (0.42) | SMN1; SMN2MAPT | |
| SCHEMBL25694585 | 0.70 | SMN1; SMN2 (0.43) | SMN1; SMN2MAPT | |
| SCHEMBL28630183 | 0.69 | GSK3B (0.34) | SMN1; SMN2CDK2 | |
| SCHEMBL16320539 | 0.69 | ALDH1A1 (0.40) | SMN1; SMN2CDK2CSNK1DMAPK11MAPK14 | |
| SCHEMBL17059212 | 0.69 | CCNE2 (0.49) | SMN1; SMN2CDK2MAPT | |
| SCHEMBL20356534 | 0.69 | CDK6 (0.37) | SMN1; SMN2CDK2 | |
| SCHEMBL20740598 | 0.69 | CDK6 (0.57) | SMN1; SMN2CDK2 | |
| SCHEMBL29592215 | 0.69 | CDK6 (0.37) | SMN1; SMN2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017133701-A1 | CERTAIN PROTEIN KINASE INHIBITORS | SHANGHAI FOCHON PHARMACEUTICAL CO., LTD. (CN) | 2017-08-10 | — | — | WO | disclosed |