Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSC | P53634 | 8/20 | 0.41 |
| ▸ | CTSK | P43235 | 5/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.33 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.33 |
| ▸ | USP28 | Q96RU2 | 2/20 | 0.33 |
| ▸ | USP25 | Q9UHP3 | 2/20 | 0.33 |
| ▸ | ACACB | O00763 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21457800 | 0.85 | NR1H2 (0.41) | CTSCCTSKCHRM2 | |
| SCHEMBL29577316 | 0.85 | NR1H2 (0.41) | CTSCCTSKCHRM2 | |
| SCHEMBL19212302 | 0.83 | USP28 (0.39) | CTSCCTSKRORCPTGS1PTGS2 | |
| SCHEMBL19210936 | 0.82 | USP30 (0.33) | USP30USP28USP25ACACB | |
| SCHEMBL19212163 | 0.82 | CTSC (0.37) | CTSCCTSKUSP30ACACB | |
| SCHEMBL19212252 | 0.78 | USP28 (0.42) | CTSCCTSKUSP28USP25 | |
| SCHEMBL19210981 | 0.77 | PRKDC (0.37) | CTSCCTSKRORCUSP30ACACB | |
| SCHEMBL19210895 | 0.76 | CTSC (0.42) | CTSCCTSKRORC | |
| SCHEMBL19210897 | 0.72 | FFAR4 (0.41) | CTSCCTSKRORCUSP28USP25 | |
| SCHEMBL19211023 | 0.71 | ACACB (0.33) | PTGS1ACACBDPP4DPP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3414251-B1 | THIENOPYRAZINE CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS | FORMA THERAPEUTICS INC (US) | 2019-10-16 | — | — | EP | disclosed |
| EP-3414251-A1 | THIENOPYRAZINE CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS | Forma Therapeutics, Inc. (US) | 2018-12-19 | — | — | EP | disclosed |
| WO-2017139779-A1 | THIENOPYRAZINE CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS | FORMA THERAPEUTICS, INC. (US) | 2017-08-17 | — | — | WO | disclosed |