Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMEM97 | Q5BJF2 | 16/20 | 0.57 |
| ▸ | SIGMAR1 | Q99720 | 16/20 | 0.57 |
| ▸ | HRH1 | P35367 | 5/20 | 0.57 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.57 |
| ▸ | HRH2 | P25021 | 4/20 | 0.57 |
| ▸ | HTR1A | P08908 | 2/20 | 0.57 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.57 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.57 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.57 |
| ▸ | HTR2C | P28335 | 2/20 | 0.57 |
| ▸ | HTR1E | P28566 | 2/20 | 0.57 |
| ▸ | DRD1 | P21728 | 1/20 | 0.57 |
| ▸ | HTR1B | P28222 | 1/20 | 0.57 |
| ▸ | HTR2A | P28223 | 1/20 | 0.57 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.57 |
| ▸ | HTR2B | P41595 | 1/20 | 0.57 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.51 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1291301 | 0.87 | TMEM97 (0.57) | TMEM97SIGMAR1HRH1HRH3HRH2 | |
| SCHEMBL19212195 | 0.83 | TMEM97 (0.53) | TMEM97SIGMAR1HRH1HRH3HRH2 | |
| SCHEMBL5669206 | 0.81 | TMEM97 (0.58) | TMEM97SIGMAR1HRH1HRH3HRH2 | |
| SCHEMBL14215798 | 0.81 | TMEM97 (0.53) | TMEM97SIGMAR1HRH1HRH3HRH2 | |
| SCHEMBL975238 | 0.81 | NPSR1 (0.60) | TMEM97SIGMAR1HRH1HRH3HRH2 | |
| SCHEMBL17310201 | 0.81 | SMN1; SMN2 (0.51) | MEN1KMT2ASMN1; SMN2LMNAHTT | |
| SCHEMBL4865513 | 0.81 | LMNA (0.45) | MEN1KMT2ASMN1; SMN2LMNAHTT | |
| SCHEMBL29446179 | 0.80 | TMEM97 (0.59) | TMEM97SIGMAR1HRH1HRH3HRH2 | |
| SCHEMBL17164796 | 0.80 | TMEM97 (0.59) | TMEM97SIGMAR1HRH1HRH3HRH2 | |
| SCHEMBL9727540 | 0.79 | NPSR1 (0.68) | TMEM97SIGMAR1HRH1HRH3HRH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109071560-B | Thienopyridine carboxamides as ubiquitin-specific protease inhibitors | 瓦洛健康公司 | 2022-01-14 | — | — | CN | disclosed |
| EP-3414252-A1 | THIENOPYRIDINE CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS | Forma Therapeutics, Inc. (US) | 2018-12-19 | — | — | EP | disclosed |
| WO-2017139778-A1 | THIENOPYRIDINE CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS | FORMA THERAPEUTICS, INC. (US) | 2017-08-17 | — | — | WO | disclosed |