Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | CNR1 | P21554 | 3/20 | 0.40 |
| ▸ | CTSL | P07711 | 2/20 | 0.39 |
| ▸ | CTSS | P25774 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 3/20 | 0.38 |
| ▸ | HTR2C | P28335 | 3/20 | 0.38 |
| ▸ | HTR2B | P41595 | 3/20 | 0.38 |
| ▸ | CTSK | P43235 | 2/20 | 0.37 |
| ▸ | ESRRB | O95718 | 1/20 | 0.37 |
| ▸ | ESRRG | P62508 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19212298 | 0.85 | TAAR1 (0.49) | TAAR1SMN1; SMN2LMNACNR1MEN1 | |
| SCHEMBL22957596 | 0.84 | SMN1; SMN2 (0.53) | TAAR1SMN1; SMN2LMNAMEN1KMT2A | |
| SCHEMBL24422225 | 0.72 | CHKA (0.44) | CTSLCTSSCTSBDRD2MAPT | |
| SCHEMBL27458962 | 0.70 | SMN1; SMN2 (0.48) | TAAR1SMN1; SMN2LMNACNR1MEN1 | |
| SCHEMBL10282609 | 0.69 | MEN1 (0.62) | SMN1; SMN2LMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL24422230 | 0.68 | CHKA (0.58) | SMN1; SMN2CTSLCTSSCTSBCTSK | |
| SCHEMBL19212452 | 0.67 | SMN1; SMN2 (0.57) | SMN1; SMN2LMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL23928222 | 0.67 | KMT2A (0.53) | CNR1CTSLCTSSKMT2AHTR2A | |
| SCHEMBL12631526 | 0.67 | KMT2A (0.58) | SMN1; SMN2LMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL23291239 | 0.67 | NAMPT (0.55) | SMN1; SMN2CTSLCTSSMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3414252-A1 | THIENOPYRIDINE CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS | Forma Therapeutics, Inc. (US) | 2018-12-19 | — | — | EP | disclosed |
| WO-2017139778-A1 | THIENOPYRIDINE CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS | FORMA THERAPEUTICS, INC. (US) | 2017-08-17 | — | — | WO | disclosed |