Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 7/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | GAA | P10253 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | HTR2A | P28223 | 2/20 | 0.41 |
| ▸ | HTR2C | P28335 | 2/20 | 0.41 |
| ▸ | HTR2B | P41595 | 2/20 | 0.41 |
| ▸ | EP300 | Q09472 | 1/20 | 0.41 |
| ▸ | SCD | O00767 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 2/20 | 0.41 |
| ▸ | GFER | P55789 | 3/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19212427 | 0.85 | TAAR1 (0.43) | TAAR1MAPTSMN1; SMN2ALDH1A1GAA | |
| SCHEMBL22957596 | 0.85 | SMN1; SMN2 (0.53) | TAAR1MAPTSMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL19212263 | 0.82 | SMN1; SMN2 (0.49) | TAAR1MAPTSMN1; SMN2ALDH1A1GAA | |
| SCHEMBL21457821 | 0.75 | NAMPT (0.53) | MAPTSMN1; SMN2ALDH1A1GAANPC1 | |
| SCHEMBL19212222 | 0.74 | ME2 (0.50) | MAPTSMN1; SMN2ALDH1A1GAANPC1 | |
| SCHEMBL19210942 | 0.72 | SMN1; SMN2 (0.56) | MAPTSMN1; SMN2ALDH1A1GAANPC1 | |
| SCHEMBL29939233 | 0.72 | ALDH1A1 (0.53) | MAPTSMN1; SMN2ALDH1A1GAANPC1 | |
| SCHEMBL29414364 | 0.71 | ME2 (0.51) | MAPTSMN1; SMN2ALDH1A1LMNAGFER | |
| SCHEMBL5998572 | 0.71 | HDAC3 (0.71) | TAAR1LMNARAB9ATSHRHDAC3 | |
| SCHEMBL23928222 | 0.71 | KMT2A (0.53) | ALDH1A1NPC1HTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3414252-A1 | THIENOPYRIDINE CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS | Forma Therapeutics, Inc. (US) | 2018-12-19 | — | — | EP | disclosed |
| WO-2017139778-A1 | THIENOPYRIDINE CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS | FORMA THERAPEUTICS, INC. (US) | 2017-08-17 | — | — | WO | disclosed |