Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 7/20 | 0.66 |
| ▸ | CYP11B2 | P19099 | 6/20 | 0.66 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.42 |
| ▸ | TMPRSS4 | Q9NRS4 | 4/20 | 0.41 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.40 |
| ▸ | P2RX1 | P51575 | 2/20 | 0.40 |
| ▸ | P2RX4 | Q99571 | 2/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | CES2 | O00748 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19212951 | 0.92 | CYP11B1 (0.66) | CYP11B1CYP11B2TLR8TMPRSS4PPARG | |
| SCHEMBL19212936 | 0.89 | CYP11B1 (0.60) | CYP11B1CYP11B2PPARGPPARACES2 | |
| SCHEMBL19213000 | 0.81 | CYP11B1 (0.62) | CYP11B1CYP11B2CES2LMNAMAOA | |
| SCHEMBL17723957 | 0.80 | CYP11B1 (1.00) | CYP11B1CYP11B2 | |
| SCHEMBL26669565 | 0.80 | CYP11B1 (1.00) | CYP11B1CYP11B2 | |
| SCHEMBL19212935 | 0.80 | CYP11B1 (0.64) | CYP11B1CYP11B2KIF11PPARGPPARA | |
| SCHEMBL26813738 | 0.79 | CYP11B1 (0.52) | CYP11B1CYP11B2CES2LMNAMAPT | |
| SCHEMBL19213002 | 0.77 | CYP11B1 (0.64) | CYP11B1CYP11B2KIF11CES2KMT2A | |
| SCHEMBL19212999 | 0.75 | CYP11B1 (0.60) | CYP11B1CYP11B2PPARGPPARACES2 | |
| SCHEMBL17723862 | 0.72 | CYP11B1 (1.00) | CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9790217-B2 | Pyridinyloxy- and phenyloxy-pyrazolyl compounds | HOFFMANN-LA ROCHE INC. (US) | 2017-10-17 | — | — | US | disclosed |
| US-20170226097-A1 | PYRIDINYLOXY- AND PHENYLOXY-PYRAZOLYL COMPOUNDS | HOFFMANN-LA ROCHE INC. (US) | 2017-08-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170226097-A1 | PYRIDINYLOXY- AND PHENYLOXY-PYRAZOLYL COMPOUNDS | PDXK, PNPO, PAH | CYP11B1 84/4885CYP11B2 32/4885TLR8 4713/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.