SCHEMBL1921480

SCHEMBL1921480

Cc1ccc(Nc2ccc(-c3ccc(Nc4ccc(C)cc4C)cc3)cc2)c(C)c1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAPGEF4 Q8WZA2 4/20 0.59
MEN1 O00255 5/20 0.46
KMT2A Q03164 5/20 0.46
GAA P10253 5/20 0.46
SMN1; SMN2 Q16637 5/20 0.46
ALDH1A1 P00352 2/20 0.46
MAPT P10636 2/20 0.43
ALOX12 P18054 1/20 0.43
L3MBTL1 Q9Y468 2/20 0.42
G6PD P11413 1/20 0.42
EGFR P00533 1/20 0.42
RAB9A P51151 2/20 0.41
NPC1 O15118 1/20 0.41
LMNA P02545 1/20 0.41
NFKB1 P19838 1/20 0.41
NFKB2 Q00653 1/20 0.41
RELA Q04206 1/20 0.41
MAPK1 P28482 1/20 0.41
TDP1 Q9NUW8 1/20 0.41
MAPKAPK2 P49137 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15478852 0.98 RAPGEF4 (0.57) RAPGEF4MEN1KMT2AGAASMN1; SMN2
SCHEMBL29445703 0.94 RAPGEF4 (0.65) RAPGEF4MEN1KMT2AGAASMN1; SMN2
SCHEMBL1921159 0.94 RAPGEF4 (0.65) RAPGEF4MEN1KMT2AGAASMN1; SMN2
SCHEMBL13580077 0.93 MAPT (0.52) RAPGEF4MEN1KMT2AGAASMN1; SMN2
SCHEMBL10019438 0.93 MAPT (0.52) RAPGEF4MEN1KMT2AGAASMN1; SMN2
SCHEMBL30477867 0.93 MAPT (0.52) RAPGEF4MEN1KMT2AGAASMN1; SMN2
SCHEMBL12388896 0.93 MAPT (0.52) RAPGEF4MEN1KMT2AGAASMN1; SMN2
SCHEMBL30146931 0.91 RAPGEF4 (0.63) RAPGEF4MEN1KMT2AGAASMN1; SMN2
SCHEMBL5667044 0.91 RAPGEF4 (0.63) RAPGEF4MEN1KMT2AGAASMN1; SMN2
SCHEMBL6325460 0.91 RAPGEF4 (0.50) RAPGEF4MEN1KMT2AGAASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9709906-B2 Charge transport substance, electrophotographic photoreceptor, electrophotographic photoreceptor cartridge, and image-forming apparatus MITSUBISHI CHEMICAL CORPORATION (JP) 2017-07-18 US disclosed
US-9709906-B2 Charge transport substance, electrophotographic photoreceptor, electrophotographic photoreceptor cartridge, and image-forming apparatus MITSUBISHI CHEMICAL CORPORATION (JP) 2017-07-18 US disclosed
US-9684253-B2 Triphenylamine derivative, electrophotographic photosensitive member, and image forming apparatus KYOCERA DOCUMENT SOLUTIONS INC. (JP) 2017-06-20 US disclosed
US-9684253-B2 Triphenylamine derivative, electrophotographic photosensitive member, and image forming apparatus KYOCERA DOCUMENT SOLUTIONS INC. (JP) 2017-06-20 US disclosed
EP-2698671-B1 CHARGE-TRANSPORTING SUBSTANCE, ELECTROPHOTOGRAPHIC PHOTOSENSITIVE BODY, ELECTROPHOTOGRAPHIC PHOTOSENSITIVE BODY CARTRIDGE, AND IMAGING DEVICE MITSUBISHI CHEM CORP (JP) 2016-04-27 EP disclosed
US-20160062254-A1 TRIPHENYLAMINE DERIVATIVE, ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, AND IMAGE FORMING APPARATUS KYOCERA DOCUMENT SOLUTIONS INC. (JP) 2016-03-03 US disclosed
US-20160062254-A1 TRIPHENYLAMINE DERIVATIVE, ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, AND IMAGE FORMING APPARATUS KYOCERA DOCUMENT SOLUTIONS INC. (JP) 2016-03-03 US disclosed
US-20150355559-A1 CHARGE TRANSPORT SUBSTANCE, ELECTROPHOTOGRAPHIC PHOTORECEPTOR, ELECTROPHOTOGRAPHIC PHOTORECEPTOR CARTRIDGE, AND IMAGE-FORMING APPARATUS MITSUBISHI CHEMICAL CORPORATION (JP) 2015-12-10 US disclosed
US-20150355559-A1 CHARGE TRANSPORT SUBSTANCE, ELECTROPHOTOGRAPHIC PHOTORECEPTOR, ELECTROPHOTOGRAPHIC PHOTORECEPTOR CARTRIDGE, AND IMAGE-FORMING APPARATUS MITSUBISHI CHEMICAL CORPORATION (JP) 2015-12-10 US disclosed
EP-1528074-B1 NOVEL TRIARYLAMINE POLYMER, PROCESS FOR PRODUCING THE SAME, AND USE THEREOF TOSOH CORP (JP) 2014-03-26 EP disclosed
US-20140065532-A1 CHARGE TRANSPORT SUBSTANCE, ELECTROPHOTOGRAPHIC PHOTORECEPTOR, ELECTROPHOTOGRAPHIC PHOTORECEPTOR CARTRIDGE, AND IMAGE-FORMING APPARATUS MITSUBISHI CHEMICAL CORPORATION (JP) 2014-03-06 US disclosed
US-20140065532-A1 CHARGE TRANSPORT SUBSTANCE, ELECTROPHOTOGRAPHIC PHOTORECEPTOR, ELECTROPHOTOGRAPHIC PHOTORECEPTOR CARTRIDGE, AND IMAGE-FORMING APPARATUS MITSUBISHI CHEMICAL CORPORATION (JP) 2014-03-06 US disclosed
EP-2327739-A1 Novel triarylamine polymer, process for its production and its use TOSOH CORPORATION (JP) 2011-06-01 EP disclosed
US-7608680-B2 Triarylamine polymer, process for producing the same, and use thereof TOSOH CORPORATION (JP) 2009-10-27 US disclosed
US-20060241278-A1 Novel triarylamine polymer, process for producing the same, and use thereof TOSOH CORPORATION (JP) 2006-10-26 US disclosed
US-20060017040-A9 Novel triarylamine polymer, process for producing the same, and use thereof SUZUKI TAKAO 2006-01-26 US disclosed
EP-1528074-A1 NOVEL TRIARYLAMINE POLYMER, PROCESS FOR PRODUCING THE SAME, AND USE THEREOF Tosoh Corporation (JP) 2005-05-04 EP disclosed
US-20040262574-A1 Novel triarylamine polymer, process for producing the same, and use thereof TOSOH CORPORATION (JP) 2004-12-30 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160062254-A1 TRIPHENYLAMINE DERIVATIVE, ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, AND IMAGE FORMING APPARATUS IK, NAT1, TPT1 RAPGEF4 1994/4885MEN1 478/4885KMT2A 375/4885
US-20150355559-A1 CHARGE TRANSPORT SUBSTANCE, ELECTROPHOTOGRAPHIC PHOTORECEPTOR, ELECTROPHOTOGRAPHIC PHOTORECEPTOR CARTRIDGE, AND IMAGE-FORMING APPARATUS PDE6C, SLC18A2, SLC1A2 RAPGEF4 898/4885MEN1 3854/4885KMT2A 2929/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.