Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.63 |
| ▸ | RXRA | P19793 | 1/20 | 0.46 |
| ▸ | RXRB | P28702 | 1/20 | 0.46 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | HTR1D | P28221 | 1/20 | 0.37 |
| ▸ | HTR1B | P28222 | 1/20 | 0.37 |
| ▸ | TYR | P14679 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2293769 | 0.81 | IDO1 (0.68) | IDO1RXRARXRBNFE2L2L3MBTL1 | |
| SCHEMBL11341386 | 0.81 | IDO1 (0.68) | IDO1RXRARXRBNFE2L2L3MBTL1 | |
| SCHEMBL764954 | 0.79 | IDO1 (0.65) | IDO1RXRARXRBNFE2L2L3MBTL1 | |
| SCHEMBL11354558 | 0.77 | IDO1 (0.63) | IDO1RXRARXRBNFE2L2L3MBTL1 | |
| SCHEMBL260335 | 0.77 | IDO1 (0.63) | IDO1RXRARXRBNFE2L2L3MBTL1 | |
| SCHEMBL19121843 | 0.77 | IDO1 (0.63) | IDO1RXRARXRBNFE2L2L3MBTL1 | |
| SCHEMBL2096474 | 0.77 | IDO1 (0.63) | IDO1RXRARXRBNFE2L2L3MBTL1 | |
| SCHEMBL1715484 | 0.77 | IDO1 (1.00) | IDO1 | |
| SCHEMBL17037240 | 0.77 | IDO1 (0.63) | IDO1RXRARXRBNFE2L2L3MBTL1 | |
| SCHEMBL13160063 | 0.76 | RXRA (0.72) | IDO1RXRARXRBL3MBTL1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9724321-B2 | Histone deacetylase inhibitors | PRESIDENT & FELLOWS OF HARVARD COLLEGE (US) | 2017-08-08 | — | — | US | disclosed |