Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 19/20 | 0.40 |
| ▸ | JAK2 | O60674 | 18/20 | 0.40 |
| ▸ | ATP4A | P20648 | 1/20 | 0.37 |
| ▸ | ATP4B | P51164 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16126336 | 1.00 | JAK1 (0.40) | JAK1JAK2ATP4AATP4BTYK2 | |
| SCHEMBL16126343 | 1.00 | JAK1 (0.40) | JAK1JAK2ATP4AATP4BTYK2 | |
| SCHEMBL18093926 | 0.93 | ATP4A (0.39) | JAK1JAK2ATP4AATP4B | |
| SCHEMBL18093872 | 0.93 | ATP4A (0.39) | JAK1JAK2ATP4AATP4B | |
| SCHEMBL16101865 | 0.93 | ATP4A (0.39) | JAK1JAK2ATP4AATP4B | |
| SCHEMBL16105046 | 0.88 | JAK2 (0.42) | JAK1JAK2ATP4AATP4B | |
| SCHEMBL16126772 | 0.88 | JAK2 (0.42) | JAK1JAK2ATP4AATP4B | |
| SCHEMBL18093725 | 0.88 | JAK2 (0.42) | JAK1JAK2ATP4AATP4B | |
| SCHEMBL16126507 | 0.88 | ATP4A (0.40) | JAK1JAK2ATP4AATP4B | |
| SCHEMBL16126510 | 0.88 | ATP4A (0.40) | JAK1JAK2ATP4AATP4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9725445-B2 | Cycloalkyl nitrile pyrazolo pyridones as Janus kinase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-08-08 | — | — | US | disclosed |