Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 11/20 | 0.73 |
| ▸ | S1PR3 | Q99500 | 11/20 | 0.73 |
| ▸ | S1PR2 | O95136 | 9/20 | 0.73 |
| ▸ | S1PR4 | O95977 | 5/20 | 0.73 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.72 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.72 |
| ▸ | LPAR2 | Q9HBW0 | 3/20 | 0.69 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.69 |
| ▸ | LMNA | P02545 | 1/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.68 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.66 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.66 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.66 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9784433 | 0.96 | HRH4 (0.72) | S1PR1S1PR3S1PR2S1PR4HRH4 | |
| SCHEMBL10748421 | 0.92 | HRH4 (0.84) | S1PR1S1PR3S1PR2S1PR4HRH4 | |
| SCHEMBL9259496 | 0.92 | HRH4 (0.84) | S1PR1S1PR3S1PR2S1PR4HRH4 | |
| SCHEMBL9637156 | 0.92 | HRH4 (0.84) | S1PR1S1PR3S1PR2S1PR4HRH4 | |
| SCHEMBL10747074 | 0.92 | HRH4 (0.84) | S1PR1S1PR3S1PR2S1PR4HRH4 | |
| SCHEMBL13617924 | 0.92 | S1PR1 (0.68) | S1PR1S1PR3S1PR2S1PR4HRH4 | |
| SCHEMBL25701654 | 0.91 | HRH4 (0.70) | S1PR1S1PR3S1PR2S1PR4HRH4 | |
| SCHEMBL13093971 | 0.88 | HRH4 (0.66) | S1PR1S1PR3S1PR2S1PR4HRH4 | |
| SCHEMBL7209237 | 0.87 | HTR2A (0.63) | S1PR1S1PR3S1PR2S1PR4HRH4 | |
| SCHEMBL1810044 | 0.87 | HRH4 (0.60) | S1PR1S1PR3S1PR2S1PR4HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9725407-B2 | HDAC inhibitors | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2017-08-08 | — | — | US | disclosed |