Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.84 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.84 |
| ▸ | LMNA | P02545 | 1/20 | 0.79 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.78 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.75 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.75 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.75 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.67 |
| ▸ | S1PR1 | P21453 | 6/20 | 0.62 |
| ▸ | S1PR3 | Q99500 | 6/20 | 0.62 |
| ▸ | S1PR2 | O95136 | 5/20 | 0.62 |
| ▸ | S1PR4 | O95977 | 3/20 | 0.62 |
| ▸ | MAOA | P21397 | 1/20 | 0.61 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.58 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9637156 | 1.00 | HRH4 (0.84) | HRH4HRH3LMNASMN1; SMN2CYP1A2 | |
| SCHEMBL10748421 | 1.00 | HRH4 (0.84) | HRH4HRH3LMNASMN1; SMN2CYP1A2 | |
| SCHEMBL10747074 | 1.00 | HRH4 (0.84) | HRH4HRH3LMNASMN1; SMN2CYP1A2 | |
| SCHEMBL5936699 | 0.94 | HRH4 (0.96) | HRH4HRH3LMNASMN1; SMN2CYP1A2 | |
| SCHEMBL21361201 | 0.94 | HRH4 (0.75) | HRH4HRH3LMNASMN1; SMN2CYP1A2 | |
| SCHEMBL25018783 | 0.94 | HRH4 (0.75) | HRH4HRH3LMNASMN1; SMN2CYP1A2 | |
| SCHEMBL9784433 | 0.92 | HRH4 (0.72) | HRH4HRH3LMNASMN1; SMN2CYP1A2 | |
| SCHEMBL14288543 | 0.92 | CHRM2 (0.81) | HRH4HRH3LMNASMN1; SMN2CYP1A2 | |
| SCHEMBL19217017 | 0.92 | S1PR1 (0.73) | HRH4HRH3LMNASMN1; SMN2CYP1A2 | |
| SCHEMBL18485193 | 0.92 | CHRM2 (0.81) | HRH4HRH3LMNASMN1; SMN2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5384425-A | Diurea derivatives useful as medicaments and processes for the preparation thereof | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1995-01-24 | — | — | US | disclosed |
| EP-0325397-B1 | DIUREA DERIVATIVES USEFUL AS MEDICAMENTS AND PROCESSES FOR THE PREPARATION THEREOF | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1993-08-18 | — | — | EP | disclosed |
| US-5227492-A | Anticholesterol agents | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1993-07-13 | — | — | US | disclosed |
| US-5166429-A | Enzyme inhibitors of acylcoenzyme A cholesterol transferase as anticholesterol agents or antideposit agents | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1992-11-24 | — | — | US | disclosed |
| US-5091419-A | Anticholesterol agent | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1992-02-25 | — | — | US | disclosed |
| EP-0325397-A1 | Diurea derivatives useful as medicaments and processes for the preparation thereof | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1989-07-26 | — | — | EP | disclosed |