Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 7/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 6/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.44 |
| ▸ | MEF2D | Q14814 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8195919 | 1.00 | HDAC3 (0.44) | HDAC3HDAC6HDAC4HDAC1HDAC8 | |
| SCHEMBL3457451 | 0.88 | HDAC3 (0.49) | HDAC3HDAC6HDAC4HDAC1HDAC8 | |
| SCHEMBL3457444 | 0.88 | HDAC3 (0.49) | HDAC3HDAC6HDAC4HDAC1HDAC8 | |
| SCHEMBL13539401 | 0.85 | TAS1R3 (0.37) | SMN1; SMN2RAB9AKMT2AMEN1MAPT | |
| SCHEMBL1411125 | 0.83 | TAS1R3 (0.45) | HDAC3HDAC6HDAC4HDAC1HDAC8 | |
| SCHEMBL1411128 | 0.83 | TAS1R3 (0.45) | HDAC3HDAC6HDAC4HDAC1HDAC8 | |
| SCHEMBL1411131 | 0.83 | TAS1R3 (0.45) | HDAC3HDAC6HDAC4HDAC1HDAC8 | |
| SCHEMBL12810113 | 0.83 | HDAC3 (0.56) | HDAC3HDAC6HDAC4HDAC1HDAC8 | |
| SCHEMBL19723001 | 0.83 | HDAC3 (0.56) | HDAC3HDAC6HDAC4HDAC1HDAC8 | |
| SCHEMBL19217096 | 0.81 | SAE1 (0.37) | HDAC3HDAC6HDAC4HDAC1HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2069291-B1 | HDAC INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2017-12-20 | — | — | EP | disclosed |
| US-9725407-B2 | HDAC inhibitors | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2017-08-08 | — | — | US | disclosed |