Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 2/20 | 0.37 |
| ▸ | MC4R | P32245 | 1/20 | 0.37 |
| ▸ | MC5R | P33032 | 1/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | PDE8B | O95263 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.33 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.33 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | NAAA | Q02083 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19218107 | 0.86 | PARP1 (0.46) | PARP1ATMMC4RMC5REPHX1 | |
| SCHEMBL9098808 | 0.84 | PARP1 (0.50) | PARP1MC4RMC5RSMN1; SMN2 | |
| SCHEMBL1149942 | 0.84 | PARP1 (0.50) | PARP1MC4RMC5RSMN1; SMN2 | |
| SCHEMBL19834189 | 0.81 | PARP1 (0.52) | PARP1HSD17B10SMN1; SMN2 | |
| SCHEMBL9942281 | 0.79 | PARP1 (0.41) | PARP1MC4RMC5REPHX1HSD17B10 | |
| SCHEMBL15606366 | 0.79 | PARP1 (0.41) | PARP1MC4RMC5REPHX1HSD17B10 | |
| SCHEMBL873916 | 0.79 | PARP1 (0.51) | PARP1ATMMC4RMC5REPHX1 | |
| SCHEMBL15606432 | 0.79 | PARP1 (0.41) | PARP1MC4RMC5REPHX1HSD17B10 | |
| SCHEMBL27887715 | 0.79 | PARP1 (0.51) | PARP1ATMMC4RMC5REPHX1 | |
| SCHEMBL336578 | 0.78 | PARP1 (0.54) | PARP1ATMHSD17B10SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2864318-B1 | 2-AMINOPYRAZINE DERIVATIVES AS CSF-1R KINASE INHIBITORS | MACROPHAGE PHARMA LTD (GB) | 2017-08-09 | — | — | EP | disclosed |