Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | NAAA | Q02083 | 2/20 | 0.40 |
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.39 |
| ▸ | TPSD1 | Q9BZJ3 | 2/20 | 0.39 |
| ▸ | TPSG1 | Q9NRR2 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 2/20 | 0.37 |
| ▸ | MC4R | P32245 | 1/20 | 0.34 |
| ▸ | MC5R | P33032 | 1/20 | 0.34 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.32 |
| ▸ | PDE8B | O95263 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19217931 | 0.86 | PARP1 (0.48) | PARP1NAAATPSAB1TPSD1TPSG1 | |
| SCHEMBL19218108 | 0.84 | PARP1 (0.47) | PARP1ATM | |
| SCHEMBL31218759 | 0.81 | PARP1 (0.52) | PARP1ATMHSD17B10 | |
| SCHEMBL18129846 | 0.80 | PARP1 (0.50) | PARP1ATM | |
| SCHEMBL5224952 | 0.80 | PARP1 (0.50) | PARP1ATM | |
| SCHEMBL9052251 | 0.80 | PARP1 (0.50) | PARP1ATMHSD17B10 | |
| SCHEMBL5224956 | 0.80 | PARP1 (0.50) | PARP1ATM | |
| SCHEMBL16846248 | 0.80 | PARP1 (0.50) | PARP1ATMHSD17B10 | |
| SCHEMBL30872577 | 0.79 | PARP1 (0.49) | PARP1ATM | |
| SCHEMBL6110934 | 0.79 | PARP1 (0.49) | PARP1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2864318-B1 | 2-AMINOPYRAZINE DERIVATIVES AS CSF-1R KINASE INHIBITORS | MACROPHAGE PHARMA LTD (GB) | 2017-08-09 | — | — | EP | disclosed |