Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 2/20 | 0.32 |
| ▸ | CA1 | P00915 | 2/20 | 0.32 |
| ▸ | CA2 | P00918 | 2/20 | 0.32 |
| ▸ | CA4 | P22748 | 2/20 | 0.32 |
| ▸ | CA9 | Q16790 | 2/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.31 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.31 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.31 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31218759 | 0.87 | PARP1 (0.52) | PARP1ATMCA1CA2CA4 | |
| SCHEMBL30872577 | 0.87 | PARP1 (0.49) | PARP1ATMCA1CA2CA4 | |
| SCHEMBL6110934 | 0.87 | PARP1 (0.49) | PARP1ATMCA1CA2CA4 | |
| SCHEMBL18129846 | 0.86 | PARP1 (0.50) | PARP1ATMCA1CA2CA4 | |
| SCHEMBL5224952 | 0.86 | PARP1 (0.50) | PARP1ATMCA1CA2CA4 | |
| SCHEMBL5224956 | 0.86 | PARP1 (0.50) | PARP1ATMCA1CA2CA4 | |
| SCHEMBL16846248 | 0.86 | PARP1 (0.50) | PARP1ATMCA1CA2CA4 | |
| SCHEMBL9052251 | 0.86 | PARP1 (0.50) | PARP1ATMCA1CA2CA4 | |
| SCHEMBL31476848 | 0.85 | PARP1 (0.49) | PARP1ATMCA1CA2CA4 | |
| SCHEMBL19218107 | 0.84 | PARP1 (0.46) | PARP1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2864318-B1 | 2-AMINOPYRAZINE DERIVATIVES AS CSF-1R KINASE INHIBITORS | MACROPHAGE PHARMA LTD (GB) | 2017-08-09 | — | — | EP | disclosed |