Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX1 | P51575 | 2/20 | 0.46 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.40 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.40 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | XBP1 | P17861 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.39 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.39 |
| ▸ | TNF | P01375 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19220853 | 0.90 | MAPT (0.50) | P2RX1TRPV1KMT2AMEN1LMNA | |
| SCHEMBL19220850 | 0.76 | DNA2 (0.54) | P2RX1KMT2AMEN1LMNAMAPT | |
| SCHEMBL19220855 | 0.75 | MAPT (0.48) | KMT2AMEN1LMNAMAPTPOLB | |
| SCHEMBL6200991 | 0.71 | MAPT (0.49) | KMT2AMEN1LMNAMAPTPOLB | |
| SCHEMBL1549304 | 0.71 | P2RX1 (0.65) | P2RX1TRPV1KMT2AMEN1LMNA | |
| SCHEMBL19220851 | 0.70 | KMT2A (0.47) | KMT2ALMNAPOLBMAPK1SMN1; SMN2 | |
| SCHEMBL31078123 | 0.69 | P2RX1 (0.65) | P2RX1KMT2AMEN1LMNAMAPT | |
| SCHEMBL6984531 | 0.69 | MEN1 (0.53) | KMT2AMEN1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL18341392 | 0.68 | SMN1; SMN2 (0.53) | P2RX1TRPV1LMNANPSR1SMN1; SMN2 | |
| SCHEMBL6195248 | 0.68 | HPGD (0.58) | KMT2AMEN1LMNAPOLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11780815-B2 | DNA2 inhibitors for cancer treatment | CITY OF HOPE (US) | 2023-10-10 | — | — | US | disclosed |
| US-20180134664-A1 | DNA2 INHIBITORS FOR CANCER TREATMENT | CITY OF HOPE | 2018-05-17 | — | — | US | disclosed |
| US-9932310-B2 | DNA2 inhibitors for cancer treatment | CITY OF HOPE (US) | 2018-04-03 | — | — | US | disclosed |
| US-20170226063-A1 | DNA2 INHIBITORS FOR CANCER TREATMENT | CITY OF HOPE | 2017-08-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180134664-A1 | DNA2 INHIBITORS FOR CANCER TREATMENT | DNA2, TOP2A, TOP2B | P2RX1 4524/4885TRPV1 4867/4885KMT2A 470/4885 |
| US-20170226063-A1 | DNA2 INHIBITORS FOR CANCER TREATMENT | DNA2, TOP2A, TOP2B | P2RX1 4524/4885TRPV1 4867/4885KMT2A 470/4885 |
| US-11780815-B2 | DNA2 inhibitors for cancer treatment | DNA2, TOP2A, TOP2B | P2RX1 4524/4885TRPV1 4867/4885KMT2A 470/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.