Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 1.00 |
| ▸ | MEN1 | O00255 | 3/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 3/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 1.00 |
| ▸ | GAA | P10253 | 1/20 | 1.00 |
| ▸ | CA9 | Q16790 | 1/20 | 0.62 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.50 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.50 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.50 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HTR5A | P47898 | 2/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL407439 | 0.81 | NPC1 (0.70) | MAPTMEN1KMT2AKDM4EGAA | |
| SCHEMBL23876098 | 0.79 | MEN1 (0.64) | MAPTMEN1KMT2AKDM4EGAA | |
| SCHEMBL28378777 | 0.77 | MAPT (0.62) | MAPTMEN1KMT2AKDM4EGAA | |
| SCHEMBL5383879 | 0.77 | MAPT (0.62) | MAPTMEN1KMT2AKDM4EGAA | |
| SCHEMBL30105853 | 0.77 | MAPT (0.62) | MAPTMEN1KMT2AKDM4EGAA | |
| SCHEMBL29485904 | 0.77 | MAPT (0.62) | MAPTMEN1KMT2AKDM4EGAA | |
| SCHEMBL6969939 | 0.77 | MAPT (0.62) | MAPTMEN1KMT2AKDM4EGAA | |
| SCHEMBL6964275 | 0.77 | MAPT (0.62) | MAPTMEN1KMT2AKDM4EGAA | |
| SCHEMBL521524 | 0.77 | CA9 (1.00) | MAPTMEN1KMT2AKDM4EGAA | |
| SCHEMBL29485939 | 0.77 | MAPT (0.62) | MAPTMEN1KMT2AKDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023205344-A1 | SMALL MOLECULE MODULATORS OF HUMAN PREGNANE X RECEPTOR | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2023-10-26 | — | — | WO | disclosed |
| WO-2023205344-A1 | SMALL MOLECULE MODULATORS OF HUMAN PREGNANE X RECEPTOR | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2023-10-26 | — | — | WO | disclosed |
| US-9908890-B2 | Selective inhibitors of constitutive androstane receptor | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2018-03-06 | — | — | US | disclosed |
| US-9908890-B2 | Selective inhibitors of constitutive androstane receptor | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2018-03-06 | — | — | US | disclosed |
| US-20170226115-A1 | SELECTIVE INHIBITORS OF CONSTITUTIVE ANDROSTANE RECEPTOR | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2017-08-10 | — | — | US | disclosed |
| US-20170226115-A1 | SELECTIVE INHIBITORS OF CONSTITUTIVE ANDROSTANE RECEPTOR | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2017-08-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170226115-A1 | SELECTIVE INHIBITORS OF CONSTITUTIVE ANDROSTANE RECEPTOR | NR1I2, NR1I3, AR | MAPT 2875/4885MEN1 4383/4885KMT2A 3595/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.