SCHEMBL407439

SCHEMBL407439

c1ccc2c(c1)CCc1ccccc1N2

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 2/20 0.70
MAPK13 O15264 1/20 0.70
MAPK12 P53778 1/20 0.70
MAPK11 Q15759 1/20 0.70
MAPK14 Q16539 1/20 0.70
MAPT P10636 4/20 0.65
MEN1 O00255 3/20 0.65
KMT2A Q03164 3/20 0.65
KDM4E B2RXH2 2/20 0.65
GAA P10253 2/20 0.65
ALDH1A1 P00352 1/20 0.55
AHR P35869 1/20 0.52
PDK2 Q15119 1/20 0.52
HSP90AA1 P07900 1/20 0.52
THRB P10828 1/20 0.52
HK1 P19367 1/20 0.52
MAPK1 P28482 1/20 0.52
RECQL P46063 1/20 0.52
RAB9A P51151 1/20 0.52
GALK1 P51570 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4861947 0.89 MAPT (0.72) NPC1MAPK13MAPK12MAPK11MAPK14
SCHEMBL22044245 0.87 MAPT (0.63) NPC1MAPK13MAPK12MAPK11MAPK14
SCHEMBL6469101 0.85 NPC1 (0.72) NPC1MAPK13MAPK12MAPK11MAPK14
SCHEMBL11099268 0.85 HTR2C (0.68) NPC1MAPK13MAPK12MAPK11MAPK14
SCHEMBL88725 0.83 MEN1 (0.65) NPC1MAPK13MAPK12MAPK11MAPK14
SCHEMBL134599 0.83 NPC1 (0.57) NPC1MAPK13MAPK12MAPK11MAPK14
SCHEMBL3260854 0.83 NPC1 (0.57) NPC1MAPK13MAPK12MAPK11MAPK14
SCHEMBL4227502 0.83 NPC1 (1.00) NPC1MAPK13MAPK12MAPK11MAPK14
SCHEMBL9688137 0.83 NPC1 (0.57) NPC1MAPK13MAPK12MAPK11MAPK14
SCHEMBL10032 0.83 NPC1 (1.00) NPC1MAPK13MAPK12MAPK11MAPK14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 2719 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12250877-B2 Organic light-emitting device and apparatus including the same SAMSUNG DISPLAY CO., LTD. (KR) 2025-03-11 US claimed
US-20240216316-A1 DIHOMO-GAMMA LINOLENIC ACID (DGLA) IS A NOVEL SENOLYTIC BUCK INST RES AGING (US) 2024-07-04 US claimed
CN-115703806-B Phosphine ligand of pyrazole-amide framework, and preparation method and application thereof 香港理工大学深圳研究院 2024-05-14 CN claimed
CN-117990817-A Method for measuring impurity content in pharmaceutical intermediate acyl chloride iminodibenzyl by utilizing HPLC 江苏慈星药业有限公司 2024-05-07 CN claimed
CN-117903864-A High-performance special synthetic lubricating oil and preparation method thereof 哈尔滨紫杉油脂股份有限公司 2024-04-19 CN claimed
US-20240052256-A1 BENZAZEPINE COMPOUNDS AS ANTIOXIDANTS FOR LUBRICANT COMPOSITIONS THE LUBRIZOL CORPORATION 2024-02-15 US claimed
CN-117430553-A Synthesis method of iminodibenzyl 河北八亿时空药业有限公司 2024-01-23 CN claimed
CN-117377651-A Cationic lipid with side chain containing functional groups and application thereof 厦门赛诺邦格生物科技股份有限公司 2024-01-09 CN claimed
CN-116836117-A Iminodibenzyl cyclization process and iminodibenzyl preparation process 浙江华洲药业有限公司 2023-10-03 CN claimed
CN-115057817-B Production process of iminostilbene 浙江华洋药业有限公司 2023-09-08 CN claimed
US-5034294-A Light sensitive multilayer element with electron donors and electron acceptors CANON KABUSHIKI KAISHA (JP) 1991-07-23 US claimed
EP-0396134-A1 Process for the preparation of 5H-dibenz (b,f) azepines ALKALOIDA VEGYESZETI GYAR (HU) 1990-11-07 EP claimed
US-4931435-A TRICYCLIC ANTIDEPRESSANT WITH BENZYLPYRROLIDINONE; SIDE EFFECT REDUCTION BOEHRINGER INGELHEIM KG (DE) 1990-06-05 US claimed
EP-0158115-B1 PROCESS FOR THE PREPARATION OF IMINODIBENZYL CL PHARMA AKTIENGESELLSCHAFT (AT) 1989-05-31 EP claimed
EP-0280290-A2 Agent having an antidepressive activity BOEHRINGER INGELHEIM KG (DE) 1988-08-31 EP claimed
EP-0237952-A1 Process for the preparation of 5H-Dibenzo-(b, f)-azepine ORION-YHTYMÄ OY FERMION (FI) 1987-09-23 EP claimed
EP-0158115-A2 Process for the preparation of iminodibenzyl CL PHARMA AKTIENGESELLSCHAFT (AT) 1985-10-16 EP claimed
US-4249003-A Process for polycyclic amines AKTIEBOLAGET LEO (SE) 1981-02-03 US claimed
US-4013639-A PREPARATION OF ASYMMETRIC IMINODIBENZYL COMPOUNDS Kitamura, Eiichi (JA) 1977-03-22 US claimed
US-3945941-A POLYETHYLENE OR POLYPROPYLENE STORAGETANK LINERS OXIRANE CORPORATION (US) 1976-03-23 US claimed