Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | MGLL | Q99685 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 5/20 | 0.37 |
| ▸ | MAOA | P21397 | 2/20 | 0.36 |
| ▸ | CA12 | O43570 | 4/20 | 0.35 |
| ▸ | CA9 | Q16790 | 4/20 | 0.35 |
| ▸ | CA1 | P00915 | 3/20 | 0.35 |
| ▸ | CA4 | P22748 | 2/20 | 0.35 |
| ▸ | CA6 | P23280 | 2/20 | 0.35 |
| ▸ | CA5A | P35218 | 2/20 | 0.35 |
| ▸ | CA7 | P43166 | 2/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.35 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10025750 | 0.90 | MAOB (0.36) | KDM4EHSD17B10MGLLTDP1MAOB | |
| SCHEMBL17401003 | 0.88 | KDM4E (0.49) | KDM4EHSD17B10MGLLTDP1MAOB | |
| SCHEMBL13457571 | 0.88 | MAOB (0.38) | KDM4EHSD17B10MAOBMAOACA12 | |
| SCHEMBL17541501 | 0.86 | KDM4E (0.46) | KDM4EHSD17B10MGLLTDP1MAOB | |
| SCHEMBL12269272 | 0.83 | MAOB (0.51) | KDM4EHSD17B10MGLLTDP1MAOB | |
| SCHEMBL29957761 | 0.83 | MAOB (0.48) | KDM4EHSD17B10MGLLTDP1MAOB | |
| SCHEMBL20503675 | 0.81 | MAOB (0.39) | KDM4EHSD17B10MAOBMAOACA12 | |
| SCHEMBL18715093 | 0.79 | MAOB (0.39) | KDM4EHSD17B10MAOBMAOACA12 | |
| SCHEMBL29000615 | 0.78 | KDM4E (0.42) | KDM4EHSD17B10MGLLTDP1MAOB | |
| SCHEMBL2963271 | 0.77 | KDM4E (0.53) | KDM4EHSD17B10MGLLTDP1MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9309267-B2 | Compounds suitable as precursors to compounds that are useful for imaging amyloid deposits | ASTRAZENECA AB (SE) | 2016-04-12 | — | — | US | claimed |
| US-20140296534-A1 | COMPOUNDS SUITABLE AS PRECURSORS TO COMPOUNDS THAT ARE USEFUL FOR IMAGING AMYLOID DEPOSITS | ASTRAZENECA AB (SE) | 2014-10-02 | — | — | US | claimed |
| US-20120264943-A1 | Compounds Suitable As Precursors to Compounds that are Useful for Imaging Amyloid Deposits | ASTRAZENECA AB (SE) | 2012-10-18 | — | — | US | claimed |
| EP-2328891-A1 | NEW BENZOFURANS SUITABLE AS PRECURSORS TO COMPOUNDS THAT ARE USEFUL FOR IMAGING AMYLOID DEPOSITS | AstraZeneca AB (SE) | 2011-06-08 | — | — | EP | claimed |
| WO-2010024769-A1 | NEW BENZOFURANS SUITABLE AS PRECURSORS TO COMPOUNDS THAT ARE USEFUL FOR IMAGING AMYLOID DEPOSITS | ASTRAZENECA AB (SE) | 2010-03-04 | — | — | WO | claimed |
| US-20100056796-A1 | Compounds Suitable As Precursors to Compounds that are Useful for Imaging Amyloid Deposits | ASTRAZENECA AB (SE) | 2010-03-04 | — | — | US | claimed |
| US-20210346526-A1 | NOVEL DEUTERIUM SUBSTITUTED POSITRON EMISSION TOMOGRAPHY (PET) IMAGING AGENTS AND THEIR PHARMACOLOGICAL APPLICATION | FIVE ELEVEN PHARMA INC. | 2021-11-11 | — | — | US | disclosed |
| US-11071794-B2 | Deuterium substituted positron emission tomography (PET) imaging agents and their pharmacological application | FIVE ELEVEN PHARMA INC. (US) | 2021-07-27 | — | — | US | disclosed |
| US-10912849-B2 | Deuterium substituted positron emission tomography (PET) imaging agents and their pharmacological application | FIVE ELEVEN PHARMA INC. (US) | 2021-02-09 | — | — | US | disclosed |
| US-20200230263-A1 | NOVEL DEUTERIUM SUBSTITUTED POSITRON EMISSION TOMOGRAPHY (PET) IMAGING AGENTS AND THEIR PHARMACOLOGICAL APPLICATION | FIVE ELEVEN PHARMA INC. (US) | 2020-07-23 | — | — | US | disclosed |
| EP-2328891-B1 | NEW BENZOFURANS SUITABLE AS PRECURSORS TO COMPOUNDS THAT ARE USEFUL FOR IMAGING AMYLOID DEPOSITS | ASTRAZENECA AB (SE) | 2017-04-05 | — | — | EP | disclosed |
| EP-2328891-B1 | NEW BENZOFURANS SUITABLE AS PRECURSORS TO COMPOUNDS THAT ARE USEFUL FOR IMAGING AMYLOID DEPOSITS | ASTRAZENECA AB (SE) | 2017-04-05 | — | — | EP | disclosed |
| US-9309267-B2 | Compounds suitable as precursors to compounds that are useful for imaging amyloid deposits | ASTRAZENECA AB (SE) | 2016-04-12 | — | — | US | disclosed |
| US-8193363-B2 | Compounds suitable as precursors to compounds that are useful for imaging amyloid deposits | ASTRAZENECA AB (SE) | 2012-06-05 | — | — | US | disclosed |
| EP-2328891-A1 | NEW BENZOFURANS SUITABLE AS PRECURSORS TO COMPOUNDS THAT ARE USEFUL FOR IMAGING AMYLOID DEPOSITS | AstraZeneca AB (SE) | 2011-06-08 | — | — | EP | disclosed |
| WO-2010024769-A1 | NEW BENZOFURANS SUITABLE AS PRECURSORS TO COMPOUNDS THAT ARE USEFUL FOR IMAGING AMYLOID DEPOSITS | ASTRAZENECA AB (SE) | 2010-03-04 | — | — | WO | disclosed |
| WO-2010024769-A1 | NEW BENZOFURANS SUITABLE AS PRECURSORS TO COMPOUNDS THAT ARE USEFUL FOR IMAGING AMYLOID DEPOSITS | ASTRAZENECA AB (SE) | 2010-03-04 | — | — | WO | disclosed |
| US-20100056796-A1 | Compounds Suitable As Precursors to Compounds that are Useful for Imaging Amyloid Deposits | ASTRAZENECA AB (SE) | 2010-03-04 | — | — | US | disclosed |
| US-20100056796-A1 | Compounds Suitable As Precursors to Compounds that are Useful for Imaging Amyloid Deposits | ASTRAZENECA AB (SE) | 2010-03-04 | — | — | US | disclosed |
| US-20100056796-A1 | Compounds Suitable As Precursors to Compounds that are Useful for Imaging Amyloid Deposits | ASTRAZENECA AB (SE) | 2010-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11071794-B2 | Deuterium substituted positron emission tomography (PET) imaging agents and their pharmacological application | SLC18A2, SLC6A3, SLC6A2 | KDM4E 3906/4885HSD17B10 616/4885MGLL 2993/4885 |
| US-20200230263-A1 | NOVEL DEUTERIUM SUBSTITUTED POSITRON EMISSION TOMOGRAPHY (PET) IMAGING AGENTS AND THEIR PHARMACOLOGICAL APPLICATION | SLC18A2, SLC6A3, SLC6A2 | KDM4E 3635/4885HSD17B10 631/4885MGLL 3014/4885 |
| US-20210346526-A1 | NOVEL DEUTERIUM SUBSTITUTED POSITRON EMISSION TOMOGRAPHY (PET) IMAGING AGENTS AND THEIR PHARMACOLOGICAL APPLICATION | SLC18A2, SLC6A3, SLC6A2 | KDM4E 3635/4885HSD17B10 631/4885MGLL 3014/4885 |
| US-10912849-B2 | Deuterium substituted positron emission tomography (PET) imaging agents and their pharmacological application | SLC18A2, SLC6A3, SLC6A2 | KDM4E 3906/4885HSD17B10 616/4885MGLL 2993/4885 |
| US-20100056796-A1 | Compounds Suitable As Precursors to Compounds that are Useful for Imaging Amyloid Deposits | APP, PSEN1, PSEN2 | KDM4E 4113/4885HSD17B10 2119/4885MGLL 2296/4885 |
| US-20140296534-A1 | COMPOUNDS SUITABLE AS PRECURSORS TO COMPOUNDS THAT ARE USEFUL FOR IMAGING AMYLOID DEPOSITS | APP, PSEN1, PSEN2 | KDM4E 4113/4885HSD17B10 2119/4885MGLL 2296/4885 |
| US-20120264943-A1 | Compounds Suitable As Precursors to Compounds that are Useful for Imaging Amyloid Deposits | APP, PSEN1, PSEN2 | KDM4E 4113/4885HSD17B10 2119/4885MGLL 2296/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.