Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 9/20 | 0.36 |
| ▸ | PLA2G7 | Q13093 | 8/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 2/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15900764 | 0.92 | PLA2G7 (0.39) | GPR84PLA2G7PDE4A | |
| SCHEMBL15900763 | 0.92 | PLA2G7 (0.39) | GPR84PLA2G7PDE4A | |
| SCHEMBL15901086 | 0.92 | PLA2G7 (0.39) | GPR84PLA2G7PDE4A | |
| SCHEMBL15901517 | 0.89 | PLA2G7 (0.42) | PLA2G7 | |
| SCHEMBL15901405 | 0.86 | PLA2G7 (0.41) | GPR84PLA2G7 | |
| SCHEMBL15900887 | 0.86 | PLA2G7 (0.41) | GPR84PLA2G7 | |
| SCHEMBL15901245 | 0.86 | PLA2G7 (0.41) | GPR84PLA2G7 | |
| SCHEMBL15901024 | 0.85 | PLA2G7 (0.39) | GPR84PLA2G7PDE4A | |
| SCHEMBL15901026 | 0.85 | PLA2G7 (0.39) | GPR84PLA2G7PDE4A | |
| SCHEMBL15901112 | 0.85 | PLA2G7 (0.39) | GPR84PLA2G7PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2948452-B1 | 2,3-DIHYDROIMIDAZOL[1,2-C]PYRIMIDIN-5(1H)-ONE BASED LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A2 (LP-PLA2) INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2017-08-09 | — | — | EP | disclosed |