Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | CES2 | O00748 | 2/20 | 0.39 |
| ▸ | CES1 | P23141 | 2/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.30 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25489570 | 0.81 | CA12 (0.45) | CA12CA1CA9CES2CES1 | |
| SCHEMBL318939 | 0.77 | CA12 (0.41) | CA12CA1CA9CES2CES1 | |
| SCHEMBL19135687 | 0.77 | CA12 (0.41) | CA12CA1CA9CES2CES1 | |
| SCHEMBL25485523 | 0.77 | CA12 (0.41) | CA12CA1CA9CES2CES1 | |
| SCHEMBL7812223 | 0.75 | NR1H2 (0.41) | CA12CA1CA9 | |
| SCHEMBL9693899 | 0.71 | CES2 (0.42) | CA12CA1CA9CES2CES1 | |
| SCHEMBL15738294 | 0.71 | CA12 (0.36) | CA12CA1CA9CES2CES1 | |
| SCHEMBL1330926 | 0.71 | CA12 (0.36) | CA12CA1CA9CES2CES1 | |
| SCHEMBL7808940 | 0.71 | CA12 (0.36) | CA12CA1CA9CES2CES1 | |
| SCHEMBL3169018 | 0.71 | CYP2C9 (0.43) | CA12CA1CA9CES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2948452-B1 | 2,3-DIHYDROIMIDAZOL[1,2-C]PYRIMIDIN-5(1H)-ONE BASED LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A2 (LP-PLA2) INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2017-08-09 | — | — | EP | disclosed |