Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | FABP7 | O15540 | 1/20 | 0.46 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6876556 | 0.85 | GLA (0.44) | TSHRFABP7FABP5ALDH1A1MAPK1 | |
| SCHEMBL7052295 | 0.83 | TSHR (0.45) | TSHRFABP7FABP5ALDH1A1MAPK1 | |
| SCHEMBL6259204 | 0.76 | TSHR (0.58) | TSHRFABP7FABP5ALDH1A1MAPK1 | |
| SCHEMBL10062407 | 0.76 | TSHR (0.58) | TSHRFABP7FABP5ALDH1A1MAPK1 | |
| SCHEMBL4877662 | 0.76 | TSHR (0.58) | TSHRFABP7FABP5ALDH1A1MAPK1 | |
| SCHEMBL5971142 | 0.75 | TSHR (0.52) | TSHRFABP7FABP5ALDH1A1MAPK1 | |
| SCHEMBL16915209 | 0.74 | TSHR (0.42) | TSHRFABP7FABP5ALDH1A1MAPK1 | |
| SCHEMBL15251729 | 0.73 | TSHR (0.59) | TSHRFABP7FABP5ALDH1A1MAPK1 | |
| SCHEMBL629930 | 0.73 | TSHR (0.59) | TSHRFABP7FABP5ALDH1A1MAPK1 | |
| SCHEMBL20418703 | 0.73 | TSHR (0.59) | TSHRFABP7FABP5ALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2867225-B1 | PYRROLIDINE DERIVATIVES AND THEIR USE AS COMPLEMENT PATHWAY MODULATORS | NOVARTIS AG (CH) | 2017-08-09 | — | — | EP | disclosed |