Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 1/20 | 0.50 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.50 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 7/20 | 0.47 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 5/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.40 |
| ▸ | HTR1B | P28222 | 4/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1924469 | 0.94 | CHRNB4 (0.46) | CHRNB4CHRNA3CHRNA7CA2MRGPRX4 | |
| SCHEMBL3791638 | 0.86 | CA2 (0.51) | CHRNB4CHRNA3CHRNA7CA2MRGPRX4 | |
| SCHEMBL17541419 | 0.83 | MRGPRX4 (0.47) | CHRNB4CHRNA3CHRNA7CA2MRGPRX4 | |
| SCHEMBL827016 | 0.80 | CHRNB4 (0.56) | CHRNB4CHRNA3CHRNA7CA2MRGPRX4 | |
| SCHEMBL3541660 | 0.80 | CHRNB4 (0.56) | CHRNB4CHRNA3CHRNA7CA2MRGPRX4 | |
| SCHEMBL7928373 | 0.78 | CHRNB4 (0.51) | CHRNB4CHRNA3CHRNA7CA2MRGPRX4 | |
| SCHEMBL28618849 | 0.76 | MRGPRX4 (0.49) | CHRNB4CHRNA3CHRNA7CA2MRGPRX4 | |
| SCHEMBL20503675 | 0.75 | MAOB (0.39) | CA2CA12 | |
| SCHEMBL8751807 | 0.74 | NQO1 (0.63) | CA2CA12 | |
| SCHEMBL27938239 | 0.74 | MAPK1 (0.58) | CHRNB4CHRNA3CHRNA7CYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9309267-B2 | Compounds suitable as precursors to compounds that are useful for imaging amyloid deposits | ASTRAZENECA AB (SE) | 2016-04-12 | — | — | US | claimed |
| US-20180344881-A1 | FORMULATIONS FOR 2-HETEROARYL SUBSTITUTED BENZOFURANS | NAVIDEA BIOPHARMACEUTICALS, INC. | 2018-12-06 | — | — | US | disclosed |
| EP-3377058-A1 | FORMULATIONS FOR 2-HETEROARYL SUBSTITUTED BENZOFURANS | Navidea Biopharmaceuticals, Inc. (US) | 2018-09-26 | — | — | EP | disclosed |
| EP-2328891-B1 | NEW BENZOFURANS SUITABLE AS PRECURSORS TO COMPOUNDS THAT ARE USEFUL FOR IMAGING AMYLOID DEPOSITS | ASTRAZENECA AB (SE) | 2017-04-05 | — | — | EP | disclosed |
| EP-2328891-B1 | NEW BENZOFURANS SUITABLE AS PRECURSORS TO COMPOUNDS THAT ARE USEFUL FOR IMAGING AMYLOID DEPOSITS | ASTRAZENECA AB (SE) | 2017-04-05 | — | — | EP | disclosed |
| US-9309267-B2 | Compounds suitable as precursors to compounds that are useful for imaging amyloid deposits | ASTRAZENECA AB (SE) | 2016-04-12 | — | — | US | disclosed |
| US-9309267-B2 | Compounds suitable as precursors to compounds that are useful for imaging amyloid deposits | ASTRAZENECA AB (SE) | 2016-04-12 | — | — | US | disclosed |
| US-9309267-B2 | Compounds suitable as precursors to compounds that are useful for imaging amyloid deposits | ASTRAZENECA AB (SE) | 2016-04-12 | — | — | US | disclosed |
| US-20140296534-A1 | COMPOUNDS SUITABLE AS PRECURSORS TO COMPOUNDS THAT ARE USEFUL FOR IMAGING AMYLOID DEPOSITS | ASTRAZENECA AB (SE) | 2014-10-02 | — | — | US | disclosed |
| US-20140296534-A1 | COMPOUNDS SUITABLE AS PRECURSORS TO COMPOUNDS THAT ARE USEFUL FOR IMAGING AMYLOID DEPOSITS | ASTRAZENECA AB (SE) | 2014-10-02 | — | — | US | disclosed |
| US-20120264943-A1 | Compounds Suitable As Precursors to Compounds that are Useful for Imaging Amyloid Deposits | ASTRAZENECA AB (SE) | 2012-10-18 | — | — | US | disclosed |
| US-8193363-B2 | Compounds suitable as precursors to compounds that are useful for imaging amyloid deposits | ASTRAZENECA AB (SE) | 2012-06-05 | — | — | US | disclosed |
| US-8193363-B2 | Compounds suitable as precursors to compounds that are useful for imaging amyloid deposits | ASTRAZENECA AB (SE) | 2012-06-05 | — | — | US | disclosed |
| US-8193363-B2 | Compounds suitable as precursors to compounds that are useful for imaging amyloid deposits | ASTRAZENECA AB (SE) | 2012-06-05 | — | — | US | disclosed |
| EP-2328891-A1 | NEW BENZOFURANS SUITABLE AS PRECURSORS TO COMPOUNDS THAT ARE USEFUL FOR IMAGING AMYLOID DEPOSITS | AstraZeneca AB (SE) | 2011-06-08 | — | — | EP | disclosed |
| WO-2010024769-A1 | NEW BENZOFURANS SUITABLE AS PRECURSORS TO COMPOUNDS THAT ARE USEFUL FOR IMAGING AMYLOID DEPOSITS | ASTRAZENECA AB (SE) | 2010-03-04 | — | — | WO | disclosed |
| WO-2010024769-A1 | NEW BENZOFURANS SUITABLE AS PRECURSORS TO COMPOUNDS THAT ARE USEFUL FOR IMAGING AMYLOID DEPOSITS | ASTRAZENECA AB (SE) | 2010-03-04 | — | — | WO | disclosed |
| US-20100056796-A1 | Compounds Suitable As Precursors to Compounds that are Useful for Imaging Amyloid Deposits | ASTRAZENECA AB (SE) | 2010-03-04 | — | — | US | disclosed |
| US-20100056796-A1 | Compounds Suitable As Precursors to Compounds that are Useful for Imaging Amyloid Deposits | ASTRAZENECA AB (SE) | 2010-03-04 | — | — | US | disclosed |
| US-20100056796-A1 | Compounds Suitable As Precursors to Compounds that are Useful for Imaging Amyloid Deposits | ASTRAZENECA AB (SE) | 2010-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180344881-A1 | FORMULATIONS FOR 2-HETEROARYL SUBSTITUTED BENZOFURANS | BACE2, PSEN2, PRNP | CHRNB4 2442/4885CHRNA3 3212/4885CHRNA7 3527/4885 |
| US-20100056796-A1 | Compounds Suitable As Precursors to Compounds that are Useful for Imaging Amyloid Deposits | APP, PSEN1, PSEN2 | CHRNB4 133/4885CHRNA3 362/4885CHRNA7 525/4885 |
| US-20140296534-A1 | COMPOUNDS SUITABLE AS PRECURSORS TO COMPOUNDS THAT ARE USEFUL FOR IMAGING AMYLOID DEPOSITS | APP, PSEN1, PSEN2 | CHRNB4 133/4885CHRNA3 362/4885CHRNA7 525/4885 |
| US-20120264943-A1 | Compounds Suitable As Precursors to Compounds that are Useful for Imaging Amyloid Deposits | APP, PSEN1, PSEN2 | CHRNB4 133/4885CHRNA3 362/4885CHRNA7 525/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.