Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 12/20 | 0.67 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.55 |
| ▸ | OGA | O60502 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | IDH1 | O75874 | 1/20 | 0.45 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | CDK4 | P11802 | 1/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.43 |
| ▸ | CCND1 | P24385 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.43 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.43 |
| ▸ | PRKD1 | Q15139 | 2/20 | 0.42 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29935697 | 0.90 | HRH4 (0.72) | HRH4HRH3OGACYP1A2HSD17B10 | |
| SCHEMBL859700 | 0.90 | HRH4 (0.72) | HRH4HRH3OGACYP1A2HSD17B10 | |
| SCHEMBL19233404 | 0.84 | HRH4 (0.81) | HRH4HRH3OGACYP1A2HSD17B10 | |
| SCHEMBL13619336 | 0.82 | HRH4 (0.66) | HRH4HRH3CYP1A2HSD17B10PLD1 | |
| Hydrochloric Acid SCHEMBL26599748 | 0.81 | HRH4 (0.64) | HRH4HRH3CYP1A2HSD17B10PLD1 | |
| Hydrochloric Acid SCHEMBL30619112 | 0.81 | HRH4 (0.64) | HRH4HRH3CYP1A2HSD17B10PLD1 | |
| SCHEMBL1588650 | 0.81 | HRH4 (1.00) | HRH4HRH3OGA | |
| SCHEMBL2575260 | 0.78 | HRH4 (0.71) | HRH4HRH3OGA | |
| SCHEMBL13574661 | 0.77 | HRH4 (0.80) | HRH4HRH3OGAIDH1 | |
| SCHEMBL30834235 | 0.76 | HRH3 (0.59) | HRH4HRH3CYP1A2HSD17B10PLD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9732087-B2 | Diamino-pyridine, pyrimidine, and pyridazine modulators of the histamine H4 receptor | JANSSEN PHARMACEUTICA N.V. (BE) | 2017-08-15 | — | — | US | disclosed |