Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 3/20 | 0.73 |
| ▸ | NTRK2 | Q16620 | 4/20 | 0.68 |
| ▸ | CA12 | O43570 | 4/20 | 0.51 |
| ▸ | CA1 | P00915 | 4/20 | 0.51 |
| ▸ | CA2 | P00918 | 4/20 | 0.51 |
| ▸ | CA9 | Q16790 | 4/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3973216 | 0.93 | NTRK1 (0.76) | NTRK1NTRK2CA12CA1CA2 | |
| SCHEMBL1924944 | 0.88 | NTRK1 (0.76) | NTRK1NTRK2NPSR1MAPK1PDGFRB | |
| SCHEMBL1923892 | 0.86 | NTRK1 (0.74) | NTRK1NTRK2CA12CA1CA2 | |
| SCHEMBL1924757 | 0.85 | NTRK1 (1.00) | NTRK1NTRK2MAPK1PDGFRB | |
| SCHEMBL1923992 | 0.83 | NTRK1 (0.83) | NTRK1NTRK2MAPK1PDGFRB | |
| SCHEMBL1925867 | 0.83 | NTRK1 (0.83) | NTRK1NTRK2PDGFRBTP53 | |
| SCHEMBL1925521 | 0.83 | NTRK1 (0.83) | NTRK1NTRK2MAPK1PDGFRB | |
| SCHEMBL3980180 | 0.83 | NTRK1 (0.80) | NTRK1NTRK2NPSR1MAPK1PDGFRB | |
| SCHEMBL1925441 | 0.83 | NTRK1 (0.83) | NTRK1NTRK2MAPK1PDGFRB | |
| SCHEMBL1926377 | 0.83 | NTRK1 (0.85) | NTRK1NTRK2MAPK1PDGFRBTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1948664-B1 | PYRROLOTRIAZINE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2011-06-08 | — | — | EP | disclosed |