Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 5/20 | 0.76 |
| ▸ | NTRK2 | Q16620 | 6/20 | 0.71 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 4/20 | 0.39 |
| ▸ | AURKA | O14965 | 2/20 | 0.39 |
| ▸ | LCK | P06239 | 2/20 | 0.39 |
| ▸ | FYN | P06241 | 2/20 | 0.39 |
| ▸ | LYN | P07948 | 2/20 | 0.39 |
| ▸ | PIM1 | P11309 | 2/20 | 0.39 |
| ▸ | MARK3 | P27448 | 2/20 | 0.39 |
| ▸ | FLT3 | P36888 | 2/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.39 |
| ▸ | GSK3A | P49840 | 2/20 | 0.39 |
| ▸ | GSK3B | P49841 | 2/20 | 0.39 |
| ▸ | BLK | P51451 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3980180 | 0.92 | NTRK1 (0.80) | NTRK1NTRK2PDGFRBKDRAURKA | |
| SCHEMBL1923890 | 0.88 | NTRK1 (0.73) | NTRK1NTRK2PDGFRBNPSR1MAPK1 | |
| SCHEMBL1924757 | 0.87 | NTRK1 (1.00) | NTRK1NTRK2PDGFRBMEN1KMT2A | |
| SCHEMBL1924946 | 0.86 | NTRK1 (0.75) | NTRK1NTRK2PDGFRBMEN1CYP2C9 | |
| SCHEMBL1923992 | 0.85 | NTRK1 (0.83) | NTRK1NTRK2PDGFRBKDRAURKA | |
| SCHEMBL1925441 | 0.85 | NTRK1 (0.83) | NTRK1NTRK2PDGFRBKDRAURKA | |
| SCHEMBL1925867 | 0.85 | NTRK1 (0.83) | NTRK1NTRK2PDGFRBKDRAURKA | |
| SCHEMBL1925521 | 0.85 | NTRK1 (0.83) | NTRK1NTRK2PDGFRBKDRAURKA | |
| SCHEMBL1926377 | 0.85 | NTRK1 (0.85) | NTRK1NTRK2PDGFRBMEN1KMT2A | |
| SCHEMBL1924937 | 0.84 | NTRK1 (0.88) | NTRK1NTRK2PDGFRBKDRAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1948664-B1 | PYRROLOTRIAZINE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2011-06-08 | — | — | EP | disclosed |